«RESULTS: It was previously shown in C57BL/6 mice that L. reuteri ATCC PTA 6475 in drinking waterenhancesskin wound-healing capability to occur in half the time required for matched controlanimals via up-regulation of the neuropeptide hormoneoxytocin (Poutahidis et al., 2013a). Ability to heal flesh wounds rapidly is the hallmark of sustained good health and longevity. For this reason, we have applied host capacity to repairtissues after surgical wound infliction as a surrogate marker for overall fitness. In support of this, dietary L. reuteri supplementation in mouse models has also been shown to impart a wide array of phenotypes including improved maternal care, loweredrisk for obesity, with multigenerational effects on behavior, infertility, and cancerrisks (Table 1), supporting use of this prototype probiotic microbe in further studies.»
"L. reuteri ATCC PTA 6475effects on hormone levels and thymus size of Swiss mice. L. reuteri consumption lead to statistically significant changes including (A) increased blood levels of oxytocin (Untreated N = 10, L. reuteri N = 10), (B) decreased levels of circulating corticosterone (N = 10 per group), (C) increasedthymus weight, (N = 10 per group) and (D) lower circulating neutrophil counts (N = 10 per group). Numbers on the y-axis of bar graphs correspond to the mean ± SEM of the parameter assessed; **p < 0.001, ***p < 0.0001."