1.9
ValidityScore
Valid or Invalid?
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2016Rodents
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Griffin N, Guo S, Hu X, Shan F, Wang X, Yi Z, Zhang X -
«One of the major functions of macrophages is anti-defense. Upon activation the macrophages would secret a spectrum of cytokines to be involved in inflammation process. The ELISA results indicate that LDN increases secretion of IL-12(238.943 ± 12.56 pg/ml), TNF-α(31.92 ± 9.187 pg/ml), IL-6(190.6 ± 12.99 pg/ml), IL-1β(74.28 ± 5.705 pg/ml) while IL-10 level (203.6 ± 77.82 pg/ml) is not significant statistically. This is reasonable outcome shown as Fig. 5 »
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
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#Alcoholism / drug therapy*, Analgesics, Animals, Cells, Cultured, Fengping Shan, Humans, IgG / metabolism, Immunologic Factors / pharmacology*, Inbred BALB C, Interleukin-12 / metabolism, Lymphocyte Activation / drug effects, MEDLINE, Macrophage Activation / drug effects, Macrophages / drug effects*, Macrophages / immunology, Mice, NCBI, NIH, NLM, Naltrexone / pharmacology*, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, Nitric Oxide / metabolism, Opioid, Opioid / adverse effects, PubMed Abstract, Receptors, Shengnan Guo, Substance-Related Disorders / drug therapy*, Tumor Necrosis Factor-alpha / metabolism, Zhe Yi, delta / antagonists &, doi:10.1016/j.intimp.2016.08.015, inhibitors, pmid:27561742more... -
ranked
added it
1 year ago
on May 14, 2021