DOC increases Hypertension

5.3 ValidityScore

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Proofs

2011

Publications Review

The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders
Richard J. Auchus, Walter L. Miller
«The defect in the pathway to cortisol results in accumulation of 11-deoxycortisol, and the defect in the 17-deoxy pathway in the synthesis of corticosterone in the fasciculata lead to overproduction of DOC, potentially leading to mineralocorticoid-based hypertension. »
Organism: Humans
Notable Magnitude of Effect.
ncbi.nlm.nih.gov/pmc/articles/PMC3365799
10.1210/er.2010-0013

From this research we know that
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Obviously ACTH increases Cortisol
2.0
17OHP converts to 11-deoxycortisol
(BioMindmap Proof Quality is Low.)
9.6
Cholesterol converts to Pregnenolone
2.0
Pregnenolone converts to 17α-hydroxypregnenolone
(BioMindmap Proof Quality is Low.)
9.6
LH increases cAMP
5.8
Estradiol converts to Estrone
5.8
Testosterone converts to Androstenedione
5.0
Allopregnanolone enhances GABA receptor A
5.8
Androstenedione converts to Testosterone
5.8
Estrone converts to Estradiol
5.0
P450c17 activates 17,20-lyase
5.0
P450c17 activates 17α-hydroxylase
5.3
17OHP converts to Androstenedione
5.3
Pregnenolone converts to Cortisol
5.1
ACTH inhibits ACAT
4.9
ACTH stimulates HSSL
5.1
DHT converts to 5α-androstanedione
5.3
11-deoxycortisol converts to Cortisol
5.3
17OHP converts to 11-deoxycortisol
5.3
DOC converts to Corticosterone
5.0
18OH-corticosterone converts to Aldosterone
5.3
DOC increases Hypertension
5.3
DOC converts to Aldosterone
5.3
Noradrenaline converts to Adrenaline
5.1
ACTH stimulates 18-hydroxylase
5.1
ACTH stimulates 18-oxidase
5.3
Androstenedione converts to Estrone
5.0
20α-dihydroprogesterone converts to Progesterone
5.3
Androstanediol converts to DHT
5.3
5α-dihydroprogesterone converts to Allopregnanolone
5.3
Testosterone converts to DHT
5.8
LDL converts to Cholesterol
5.3
ACTH increases cAMP
7.4
Pregnenolone converts to Progesterone
5.1
P450SCC is CYP11A1
4.3
17βHSD1 may affect Breast cancer
5.1
LDL converts to Free Cholesterol
5.3
cAMP increases P450SCC
5.3
P450С17 increases 17α-hydroxylase
5.3
P450С17 increases 17,20-lyase
5.3
17α-hydroxylase increases Cortisol
5.3
17,20-lyase increases DHEA
5.3
17α-hydroxylase decreases ACTH
5.3
Progesterone converts to DOC
5.3
Androstenedione converts to Testosterone
5.3
Testosterone converts to Estradiol
5.0
Androstenediol converts to Testosterone
5.3
17βHSD1 increases Estradiol
5.3
17OHP converts to DHT
5.0
17α-hydroxypregnenolone converts to DHEA
5.3
17OH-Allo converts to Androsterone
5.0
Androsterone converts to DHT

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