Chlorophyllin decreases TNF-α

(BioMindmap Proof Quality is Low.)

Chlorophyllin decreases TNF-α
(BioMindmap Proof Quality is Low.)

1.9 ValidityScore

Valid or Invalid? Login to vote or flag.

Proofs

2018

Rodents

Chlorophyllin Modulates Gut Microbiota and Inhibits Intestinal Inflammation to Ameliorate Hepatic Fibrosis in Mice
Dong-Xia Luo, Han Zheng, Haoche Wei, Jie Zhang, Li Zhang, Mei Luo, Meiyun Hua, Min Feng, Pengfei Wu, Richard Hu, Stephen J. Pandol, Yan Li, Yang You, Yilan Zeng, Yong Liu, Yu Liu, Yuan-Ping Han, Zishuo Chen
«After 2 weeks of adaptation, the mice were randomly divided into three groups: control, fibrosis, fibrosis treated with chlorophyllin (n = 5–7 per group); and the experiment was repeated. The liver fibrosis of mice was induced via intraperitoneal injections of carbon tetrachloride (CCl4, twice per week in a progressive regimen: 0.5 µL/g body weight for the first two treatments, then 1.5 µL/g for the next two treatments, and 2.0 µL/g for additional 6 weeks) for total 8 weeks. One group of mice was treated with same volume of mineral oil as control. One group of fibrotic mice was treated by chlorophyllin (Chengdu Tongdei Pharmaceuticals, China) in the drinking water at a dose of 25 µg/mL. Actual volume of consumption was recorded. Averagely, mice drink 3–5 mL per day. Pure drinking water was applied for the control and fibrosis groups. According to our daily observation, the green pigment did not cause any sign of abnormality or sickness. At the end of experiment, the mice were sacrifice through cervical dislocation. The liver, ileum tissues, and fecal pellets were collected and stored at −80◦C for analysis.»

«Hepatic fibrosis, as a protective measure and wound-healing program, is driven by local and systemic inflammation, featured by cytokines and growth factors. As shown in Figures 3A,B, infiltration of CD3+ lymphocytes was evident and accumulated around the central vein of the fibrotic liver. Oral administration of chlorophyllin reduced the infiltration of the T cell in the parenchyma of the liver inflammatory lesion. Accordingly, expression of inflammatory cytokine including interlukin-1beta (il-1β), interleukin-6 (il-6), and tumor necrosis factor-alpha was increased in the fibrotic liver, but it was suppressed by chlorophyllin (Figure 3C). Systemic inflammation as determined by serum TNF-alpha (tnf-α) levels was also elevated in fibrotic mice but it was down regulated by chlorophyllin treatment (Figure 3D). Plasma endotoxin levels were measured by serum LPS, which indicated that gut bacterial translocation was suppressed by chlorophyllin treatment (Figure 3E). »
Organism: Mouse / Rat (Rodents)
Notable Magnitude of Effect.
#B pathway, NF-κ, gut microbiota dysbiosis, intestinal tissue barrier, liver fibrosis, sodium copper chlorophyllin
ncbi.nlm.nih.gov/pmc/articles/PMC6288434
10.3389/fphys.2018.01671

From this research we know that
1.7
Chlorophyllin decreases TIMP-1
(BioMindmap Proof Quality is Low.)
1.9
Chlorophyllin decreases TNF-α
(BioMindmap Proof Quality is Low.)
1.9
Chlorophyllin decreases IL-6
(BioMindmap Proof Quality is Low.)
2.2
Chlorophyllin decreases LPS
(BioMindmap Proof Quality is Low.)
1.9
Chlorophyllin decreases IL-1β
(BioMindmap Proof Quality is Low.)
1.9
Chlorophyllin decreases Liver Fibrosis
(BioMindmap Proof Quality is Low.)

Add Biolink with same Proof

Add Proof

ranked