Nattokinase
may prevent
Hypertension
(BioMindmap Proof Quality is Low.)
Nattokinase
may prevent
Hypertension
(BioMindmap Proof Quality is Low.)
2.0
ValidityScore
Valid or Invalid?
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2008RCT
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Gum SN, Inoue K, Jang Y, Kim JY, Kim KC, Lee JH, Lim HH, Ogasawara K, Paik JK, Park S -
«Abstract: The objective of this study was to examine the effects of nattokinase supplementation on blood pressure in subjects with pre-hypertension or stage 1 hypertension. In a randomized, double-blind, placebo-controlled trial, 86 participants ranging from 20 to 80 years of age with an initial untreated systolic blood pressure (SBP) of 130 to 159 mmHg received nattokinase (2,000 FU/capsule) or a placebo capsule for 8 weeks. Seventy-three subjects completed the protocol. Compared with the control group, the net changes in SBP and diastolic blood pressure (DBP) were -5.55 mmHg (95% confidence interval [CI], -10.5 to -0.57 mmHg; p<0.05) and -2.84 mmHg (CI, -5.33 to -0.33 mmHg; p<0.05), respectively, after the 8-week intervention. The corresponding net change in renin activity was -1.17 ng/mL/h for the nattokinase group compared with the control group (p<0.05). In conclusion, nattokinase supplementation resulted in a reduction in SBP and DBP. These findings suggest that increased intake of nattokinase may play an important role in preventing and treating hypertension.»
- Organism: Humans
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#80 and over, Adult, Aged, Blood Pressure, Dietary Supplements*, Female, Humans, Hypertension / blood, Hypertension / diet therapy*, Ji Young Kim, Jong Ho Lee, MEDLINE, Male, Middle Aged, NCBI, NIH, NLM, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, Non-U.S. Gov', Peptidyl-Dipeptidase A / blood, Placebos, PubMed Abstract, Randomized Controlled Trial, Renin / blood, Research Support, Si Nae Gum, Soy Foods*, Subtilisins / administration &, Treatment Outcome, doi:10.1291/hypres.31.1583, dosage*, pmid:18971533more... -
ranked
added it
1 year ago
on Apr 29, 2021