Psoriasis decreases Parabacteroides

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Psoriasis decreases Parabacteroides

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2021

Publications Review

Dysregulation of the gut-brain-skin axis and key overlapping inflammatory and immune mechanisms of psoriasis and depression
Ji Y, Jiang C, Li Y, Tan Y, Wang X, Wu L, Xiao S, Zhang G
«Abstract: The occurrence, progression and recurrence of psoriasis are thought to be related to mood and psychological disorders such as depression. Psoriasis can lead to depression, and depression, in turn, exacerbates psoriasis. No specific mechanism can explain the association between psoriasis and depression. The gut-brain-skin axis has been used to explain correlations among the gut microbiota, emotional states and systemic and skin inflammation, and this axis may be associated with overlapping mechanisms between psoriasis and depression. Therefore, in the context of the gut-brain-skin axis, we systematically summarized and comparatively analysed the inflammatory and immune mechanisms of psoriasis and depression and illustrated the dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and the gut microbiota. This review provides a theoretical basis and new targets for the treatment of psoriasis and depression.»

«In patients with psoriasis, the relative abundances of the Actinobacteria and Bacteroidetes phyla have been found to be reduced, while the genera Coprobacillus, Ruminococcus, and Parabacteroides were decreased [208]. Furthermore, the progression of psoriasis often follows gastrointestinal inflammation, such as in IBD [209,210]. The decrease in bacterial diversity in patients with psoriasis strongly resembles the pattern of dysbiosis found in IBD [208]. »
Organism: Humans
Notable Magnitude of Effect.
#Guangzhong Zhang, MEDLINE, NCBI, NIH, NLM, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, PubMed Abstract, Review, Xiaoxu Wang, Yafan Li, doi:10.1016/j.biopha.2020.111065, pmid:33540138more...
pubmed.ncbi.nlm.nih.gov/33540138
10.1016/j.biopha.2020.111065

2019

Non Random CT

Psoriatic patients have a distinct structural and functional fecal microbiota compared with controls
Cohen NA, Koren O, Maharshak N, Shalev V, Shapiro J, Uzan A
«Abstract: Alterations in the gut microbiome have been implicated in the pathogenesis of several immune-mediated inflammatory diseases such as psoriatic arthritis. This work aimed to characterize the gut microbial signature of patients with active psoriasis as compared with age-, body mass index- and comorbidity-matched non-psoriatic controls and to correlate them with differential expression of metabolic pathways. Fecal samples were processed and 16S rRNA was sequenced. PICRUSt was used to perform an analysis of metabolic pathways. Of the 46 participants, 52% (n = 24) suffered from psoriasis. There was a significant difference in β-diversity between the two groups. Psoriatic patients had a significant increase in the Firmicutes and Actinobacteria phyla as compared with matched controls. At the genus level, psoriatic patients had a unique bacterial composition. At the species level, the psoriatic patients showed significant increases in the relative proportions of (false discovery rate, <0.05) in Ruminoccocus gnavus, Dorea formicigenerans and Collinsella aerofaciens, while Prevotella copri and Parabacteroides distasonis were significantly decreased as compared with controls. PICRUSt analysis revealed increases in metabolic pathways related to lipopolysaccharide function in the psoriatic cohort. These data demonstrate unique fecal microbial and metabolic signatures in psoriatic patients.»
Organism: Humans
Notable Magnitude of Effect.
#16S / genetics, Adult, Bacteria / genetics, Bacteria / isolation &, Bacteria / metabolism, Bacterial / isolation &, Case-Control Studies, Cohort Studies, DNA, Feces / microbiology*, Female, Gastrointestinal Microbiome / physiology*, Humans, Intestinal Mucosa / metabolism, Intestinal Mucosa / microbiology, Israel, Jonathan Shapiro, Lipopolysaccharides / biosynthesis, MEDLINE, Male, Middle Aged, Multicenter Study, NCBI, NIH, NLM, Nathaniel A Cohen, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, Nitsan Maharshak, Observational Study, Psoriasis / metabolism, Psoriasis / microbiology*, PubMed Abstract, RNA, Ribosomal, doi:10.1111/1346-8138.14933, pmid:31141234, purification, purification*more...
pubmed.ncbi.nlm.nih.gov/31141234
10.1111/1346-8138.14933

From this research we know that
8.9
Psoriasis decreases Ruminococcus
9.4
Psoriasis decreases Parabacteroides
8.9
Psoriasis decreases Faecalibacterium

2015

RCT

Decreased bacterial diversity characterizes the altered gut microbiota in patients with psoriatic arthritis, resembling dysbiosis in inflammatory bowel disease
Abramson SB, Artacho A, Attur M, Brusca S, Isaac S, Littman DR, Manasson J, Marmon S, Neimann A, Pamer EG, Patel T, Reddy SM, Scher JU, Ubeda C
«Results: The gut microbiota observed in patients with PsA and patients with skin psoriasis was less diverse when compared to that in healthy controls. This could be attributed to the reduced presence of several taxa. Samples from both patient groups showed a relative decrease in abundance of Coprococcus species, while samples from PsA patients were also characterized by a significant reduction in Akkermansia, Ruminococcus, and Pseudobutyrivibrio. Supernatants of fecal samples from PsA patients revealed an increase in sIgA levels and decrease in RANKL levels. Analysis of fatty acids revealed low fecal quantities of hexanoate and heptanoate in both patients with PsA and patients with psoriasis.

Conclusion: Patients with PsA and patients with skin psoriasis had a lower relative abundance of multiple intestinal bacteria. Although some genera were concomitantly decreased in both conditions, PsA samples had a lower abundance of reportedly beneficial taxa. This gut microbiota profile in PsA was similar to that previously described in patients with inflammatory bowel disease and was associated with changes in specific inflammatory proteins unique to this group, and distinct from that in patients with skin psoriasis and healthy controls. Thus, the role of the gut microbiome in the continuum of psoriasis-PsA pathogenesis and the associated immune response merits further study.»

«The gut microbiota of patients with psoriasis wascharacterized by a reduced relative abundance of the
genera Parabacteroides and Coprobacillus (Figures 1B
and D).»
Organism: Humans
Notable Magnitude of Effect.
#Adult, American Recovery and Reinvestment Act, Arthritis, Carles Ubeda, Case-Control Studies, Cytokines / metabolism, Dysbiosis / metabolism, Dysbiosis / microbiology*, Extramural, Fatty Acids / metabolism, Feces / microbiology, Female, Gastrointestinal Tract / metabolism, Gastrointestinal Tract / microbiology*, Humans, Immunoglobulin A / metabolism, Inflammatory Bowel Diseases / metabolism, Inflammatory Bowel Diseases / microbiology*, Jose U Scher, MEDLINE, Male, Microbiota*, Middle Aged, N.I.H., NCBI, NIH, NLM, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, Non-U.S. Gov', PMC4280348, Psoriasis / metabolism, Psoriasis / microbiology, Psoriatic / metabolism, Psoriatic / microbiology*, PubMed Abstract, RANK Ligand / metabolism, Research Support, Steven B Abramson, doi:10.1002/art.38892, pmid:25319745more...
pubmed.ncbi.nlm.nih.gov/25319745
10.1002/art.38892

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