Psoriasis
decreases
Parabacteroides
Psoriasis
decreases
Parabacteroides
9.4
ValidityScore
Valid or Invalid?
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2021Publications Review
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Ji Y, Jiang C, Li Y, Tan Y, Wang X, Wu L, Xiao S, Zhang G
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«Abstract: The occurrence, progression and recurrence of psoriasis are thought to be related to mood and psychological disorders such as depression. Psoriasis can lead to depression, and depression, in turn, exacerbates psoriasis. No specific mechanism can explain the association between psoriasis and depression. The gut-brain-skin axis has been used to explain correlations among the gut microbiota, emotional states and systemic and skin inflammation, and this axis may be associated with overlapping mechanisms between psoriasis and depression. Therefore, in the context of the gut-brain-skin axis, we systematically summarized and comparatively analysed the inflammatory and immune mechanisms of psoriasis and depression and illustrated the dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and the gut microbiota. This review provides a theoretical basis and new targets for the treatment of psoriasis and depression.»
- Organism: Humans
- Notable Magnitude of Effect.
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2019Non Random CT
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Cohen NA, Koren O, Maharshak N, Shalev V, Shapiro J, Uzan A
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«Abstract: Alterations in the gut microbiome have been implicated in the pathogenesis of several immune-mediated inflammatory diseases such as psoriatic arthritis. This work aimed to characterize the gut microbial signature of patients with active psoriasis as compared with age-, body mass index- and comorbidity-matched non-psoriatic controls and to correlate them with differential expression of metabolic pathways. Fecal samples were processed and 16S rRNA was sequenced. PICRUSt was used to perform an analysis of metabolic pathways. Of the 46 participants, 52% (n = 24) suffered from psoriasis. There was a significant difference in β-diversity between the two groups. Psoriatic patients had a significant increase in the Firmicutes and Actinobacteria phyla as compared with matched controls. At the genus level, psoriatic patients had a unique bacterial composition. At the species level, the psoriatic patients showed significant increases in the relative proportions of (false discovery rate, <0.05) in Ruminoccocus gnavus, Dorea formicigenerans and Collinsella aerofaciens, while Prevotella copri and Parabacteroides distasonis were significantly decreased as compared with controls. PICRUSt analysis revealed increases in metabolic pathways related to lipopolysaccharide function in the psoriatic cohort. These data demonstrate unique fecal microbial and metabolic signatures in psoriatic patients.»
- Organism: Humans
- Notable Magnitude of Effect.
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#16S / genetics, Adult, Bacteria / genetics, Bacteria / isolation &, Bacteria / metabolism, Bacterial / isolation &, Case-Control Studies, Cohort Studies, DNA, Feces / microbiology*, Female, Gastrointestinal Microbiome / physiology*, Humans, Intestinal Mucosa / metabolism, Intestinal Mucosa / microbiology, Israel, Jonathan Shapiro, Lipopolysaccharides / biosynthesis, MEDLINE, Male, Middle Aged, Multicenter Study, NCBI, NIH, NLM, Nathaniel A Cohen, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, Nitsan Maharshak, Observational Study, Psoriasis / metabolism, Psoriasis / microbiology*, PubMed Abstract, RNA, Ribosomal, doi:10.1111/1346-8138.14933, pmid:31141234, purification, purification*more...
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2015RCT
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Abramson SB, Artacho A, Attur M, Brusca S, Isaac S, Littman DR, Manasson J, Marmon S, Neimann A, Pamer EG, Patel T, Reddy SM, Scher JU, Ubeda C
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«Results: The gut microbiota observed in patients with PsA and patients with skin psoriasis was less diverse when compared to that in healthy controls. This could be attributed to the reduced presence of several taxa. Samples from both patient groups showed a relative decrease in abundance of Coprococcus species, while samples from PsA patients were also characterized by a significant reduction in Akkermansia, Ruminococcus, and Pseudobutyrivibrio. Supernatants of fecal samples from PsA patients revealed an increase in sIgA levels and decrease in RANKL levels. Analysis of fatty acids revealed low fecal quantities of hexanoate and heptanoate in both patients with PsA and patients with psoriasis.
- Organism: Humans
- Notable Magnitude of Effect.
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#Adult, American Recovery and Reinvestment Act, Arthritis, Carles Ubeda, Case-Control Studies, Cytokines / metabolism, Dysbiosis / metabolism, Dysbiosis / microbiology*, Extramural, Fatty Acids / metabolism, Feces / microbiology, Female, Gastrointestinal Tract / metabolism, Gastrointestinal Tract / microbiology*, Humans, Immunoglobulin A / metabolism, Inflammatory Bowel Diseases / metabolism, Inflammatory Bowel Diseases / microbiology*, Jose U Scher, MEDLINE, Male, Microbiota*, Middle Aged, N.I.H., NCBI, NIH, NLM, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, Non-U.S. Gov', PMC4280348, Psoriasis / metabolism, Psoriasis / microbiology, Psoriatic / metabolism, Psoriatic / microbiology*, PubMed Abstract, RANK Ligand / metabolism, Research Support, Steven B Abramson, doi:10.1002/art.38892, pmid:25319745more...
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added it
1 year ago
on Apr 16, 2021
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