5.0
ValidityScore
Valid or Invalid?
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2020Rodents
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Gu YH, Guo LL, Jin HM, Tong JD, Yang XH, Zhang BL, Zhang XM -
«Additionally, EGCG treatment significantly decreased the levels of ROS, MDA, 8-OHdG, IL-1β, IL-6, and TNF-α in kidney tissue samples compared to those in nontreated db/db mice (P < 0:05). Moreover, the level of CAT and SOD was increased in EGCG-treated db/db mice compared with that in nontreated db/db mice (P < 0:05).»
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
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2020Rodents
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Dagli AF, Gencoglu H, Karatas A, Koca SS, Orhan C, Ozgen M, Sahin K, Sahin N -
«EGCG (TeavigoR , DSM, Istanbul, Turkey) was orally administered via gavage three times a week at a dose of 50 mg/kg/day by dissolving in drinking water [16, 17]. Group III (1 day before collagen solution administration) and group IV rats (on the 14th day after arthritis development) were started EGCG treatment.»
«The serum levels of TNF-α and IL-17 in the sham group were increased compared to the control group (P < 0.01, for both). Prophylactic EGCG-induced group III rats had lower serum levels of TNF-α and IL-17 compared to the sham group. (P < 0.05, and P < 0.01, respectively). Accordingly, therapeutic EGCG-induced group IV rats had lower serum levels of TNF-α and IL-17 compared to the sham group (P < 0.01, for both). However, there was no difference among EGCG-treated groups with respect to these cytokines.» - Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
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#Adile Ferda Dagli, Ahmet Karatas, Animal*, Animals, Arthritis, Catechin / analogs &, Catechin / pharmacology, Collagen Type II, Cytokines / antagonists &, Cytokines / biosynthesis, Disease Models, Experimental / chemically induced, Experimental / drug therapy*, Experimental / metabolism, Female, Heme Oxygenase (Decyclizing) / antagonists &, Heme Oxygenase (Decyclizing) / biosynthesis, MEDLINE, NCBI, NF-E2-Related Factor 2 / antagonists &, NF-E2-Related Factor 2 / biosynthesis, NIH, NLM, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, PubMed Abstract, Rats, Suleyman Serdar Koca, Wistar, derivatives*, doi:10.1002/bab.1860, inhibitors*, pmid:31746064more... -
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2018Rodents
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Li J -
«Next, rats in the AIT model group and EGCG group were immunized by subcutaneous injection of 0.1 ml pig thyroglobulin (8 mg/ml) in incomplete Freund's adjuvant (both from Sigma-Aldrich; Merck, Darmstadt, Germany) once every 2 weeks for 6 weeks. Rats in the EGCG group were injected intraperitoneally with 0.5 mg/kg EGCG three times with a 1‑h interval at 3 h. Rats in the Sham control or AIT group were injected intraperitoneally with 100 µl of PBS. The animal experiments were conducted according to the ethical guidelines approved by the Medical Ethics Review Committee of the First Center Hospital of Tianjin (Tianjin, China). »
- Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
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ranked
added it
1 year ago
on Apr 15, 2021