Psoriasis decreases Faecalibacterium prausnitzii

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Psoriasis decreases Faecalibacterium prausnitzii

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2021

Publications Review

Dysregulation of the gut-brain-skin axis and key overlapping inflammatory and immune mechanisms of psoriasis and depression
Ji Y, Jiang C, Li Y, Tan Y, Wang X, Wu L, Xiao S, Zhang G
«Abstract: The occurrence, progression and recurrence of psoriasis are thought to be related to mood and psychological disorders such as depression. Psoriasis can lead to depression, and depression, in turn, exacerbates psoriasis. No specific mechanism can explain the association between psoriasis and depression. The gut-brain-skin axis has been used to explain correlations among the gut microbiota, emotional states and systemic and skin inflammation, and this axis may be associated with overlapping mechanisms between psoriasis and depression. Therefore, in the context of the gut-brain-skin axis, we systematically summarized and comparatively analysed the inflammatory and immune mechanisms of psoriasis and depression and illustrated the dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and the gut microbiota. This review provides a theoretical basis and new targets for the treatment of psoriasis and depression.»

«The inflammatory mechanism of DCs in psoriasis. In the early stage, damaged keratinocyte release LL-37 and self-nucleotides. pDCs are activated after the stimulation of TLR7 and TLR9 by LL-37 self-nucleotide complexes, thus inducing abundant production of IFN-α. IFN-α and LL-37 self-nucleotide complexes promote the maturation of cDCs and the differentiation of monocytes to iDCs. Interleukin IL-12 and IL-23 secreted by mature cDCs induce the maturation and differentiation of Th1 and Th17 cell and the subsequent production of IFN-γ and IL-17 to stimulate keratinocyte, contributing to psoriasis. TNF-α and IL-17 secreted by Th17 cell stimulate keratinocyte to secrete neutrophil-recruiting factors. IL-21 secreted by Th17 cell cooperates with TGF-β during Th17 cell differentiation and inhibits Treg production, thus causing an imbalance in Th17 cell/Tregs. The IL-23/IL-17 axis is highlighted in red.»

«In patients with psoriasis, the relative abundances of the Actinobacteria and Bacteroidetes phyla have been found to be reduced, while the genera Coprobacillus, Ruminococcus, and Parabacteroides were decreased. Furthermore, the progression of psoriasis often follows gastrointestinal inflammation, such as in IBD [209,210]. The decrease in bacterial diversity in patients with psoriasis strongly resembles the pattern of dysbiosis found in IBD.»

«Furthermore, short-chain fatty acids (SCFAs), a product of fibre fermentation by the gut microbiota, play a key role in promoting gut barrier integrity and exert anti-inflammatory effects.»

«Studies have found a lower abundance of Faecalibacterium prausnitzii, a significant source of SCFAs, in psoriatic patients than in healthy subjects.»

«However, the specific mechanism of this interaction is still unclear. This connection could be attributed to the increase in gut barrier permeability [213].
Studies have found a lower abundance of Faecalibacterium prausnitzii, a significant source of SCFAs, in psoriatic patients than in healthy subjects [218]. These studies suggest that microbiota alterations in psoriasis can lead to decreases in SCFAs, which results in gut barrier dysfunction and promotes the development of psoriasis.»
Organism: Humans
Notable Magnitude of Effect.
#Guangzhong Zhang, MEDLINE, NCBI, NIH, NLM, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, PubMed Abstract, Review, Xiaoxu Wang, Yafan Li, doi:10.1016/j.biopha.2020.111065, pmid:33540138
pubmed.ncbi.nlm.nih.gov/33540138
Read 10.1016/j.biopha.2020.111065

2019

Cohort

Psoriatic patients have a distinct structural and functional fecal microbiota compared with controls
Cohen NA, Koren O, Maharshak N, Shalev V, Shapiro J, Uzan A
«Abstract: Alterations in the gut microbiome have been implicated in the pathogenesis of several immune-mediated inflammatory diseases such as psoriatic arthritis. This work aimed to characterize the gut microbial signature of patients with active psoriasis as compared with age-, body mass index- and comorbidity-matched non-psoriatic controls and to correlate them with differential expression of metabolic pathways. Fecal samples were processed and 16S rRNA was sequenced. PICRUSt was used to perform an analysis of metabolic pathways. Of the 46 participants, 52% (n = 24) suffered from psoriasis. There was a significant difference in β-diversity between the two groups. Psoriatic patients had a significant increase in the Firmicutes and Actinobacteria phyla as compared with matched controls. At the genus level, psoriatic patients had a unique bacterial composition. At the species level, the psoriatic patients showed significant increases in the relative proportions of (false discovery rate, <0.05) in Ruminoccocus gnavus, Dorea formicigenerans and Collinsella aerofaciens, while Prevotella copri and Parabacteroides distasonis were significantly decreased as compared with controls. PICRUSt analysis revealed increases in metabolic pathways related to lipopolysaccharide function in the psoriatic cohort. These data demonstrate unique fecal microbial and metabolic signatures in psoriatic patients.»

«Reduced Akkermansia, Ruminococcus and Pseudobutyrovibrio in psoriatic arthritis patients compared with controls Depletion of Bifidobacteria, Lactobacilli and Faecalibacterium prausnitzii and colonization with Salmonella, Escherichia coli, Helicobacter, Campylobacter, Mycobacterium and Alcaligenes»
Organism: Humans
Notable Magnitude of Effect.
#16S / genetics, Adult, Bacteria / genetics, Bacteria / isolation &, Bacteria / metabolism, Bacterial / isolation &, Case-Control Studies, Cohort Studies, DNA, Feces / microbiology*, Female, Gastrointestinal Microbiome / physiology*, Humans, Intestinal Mucosa / metabolism, Intestinal Mucosa / microbiology, Israel, Jonathan Shapiro, Lipopolysaccharides / biosynthesis, MEDLINE, Male, Middle Aged, Multicenter Study, NCBI, NIH, NLM, Nathaniel A Cohen, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, Nitsan Maharshak, Observational Study, Psoriasis / metabolism, Psoriasis / microbiology*, PubMed Abstract, RNA, Ribosomal, doi:10.1111/1346-8138.14933, pmid:31141234, purification, purification*
pubmed.ncbi.nlm.nih.gov/31141234
Read 10.1111/1346-8138.14933

2016

Cohort

Similar Depletion of Protective Faecalibacterium prausnitzii in Psoriasis and Inflammatory Bowel Disease, but not in Hidradenitis Suppurativa
Eppinga H, Konstantinov SR, Nijsten TE, Peppelenbosch MP, Sperna Weiland CJ, Thio HB, van der Woude CJ
«The study demonstrates, for the first time, an IBD-like decrease of F. prausnitzii together with an increase of E.coli in psoriasis, supporting the presence of a gut-microbiome-skin axis in psoriasis and IBD.»

«It is known that IBD patients harbour an altered intestinal microbiome characterized by a depletion of Faecalibacterium prausnitzii and increase of Escherichia coli. At present, it is unclear whether a similar intestinal microbiome trend can be identified in IBD-associated skin disorders. We therefore investigated the F. prausnitzii and E. coli abundance in psoriasis and HS, with and without concomitant IBD.»
Organism: Humans
Notable Magnitude of Effect.
#Adolescent, Adult, Aged, Case-Control Studies, Christa J Sperna Weiland, Escherichia coli / isolation &, Faecalibacterium prausnitzii / isolation &, Feces / microbiology, Female, Gastrointestinal Microbiome*, Hester Eppinga, Hidradenitis Suppurativa / microbiology*, Humans, Inflammatory Bowel Diseases / microbiology*, MEDLINE, Male, Middle Aged, NCBI, NIH, NLM, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, Polymerase Chain Reaction, Psoriasis / microbiology*, PubMed Abstract, Sergey R Konstantinov, Young Adult, doi:10.1093/ecco-jcc/jjw070, pmid:26971052, purification*, purification*
pubmed.ncbi.nlm.nih.gov/26971052
Read 10.1093/ecco-jcc/jjw070

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Psoriasis decreases Faecalibacterium prausnitzii

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