TNF-α positively correlates with Endometriosis

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TNF-α positively correlates with Endometriosis

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Endometriosis positively correlates with TNF-α
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2012

Publications Review

Pathogenesis and pathophysiology of endometriosis
Burney RO, Giudice LC
«Abstract: Originally described over three hundred years ago, endometriosis is classically defined by the presence of endometrial glands and stroma in extrauterine locations. Endometriosis is an inflammatory, estrogen-dependent condition associated with pelvic pain and infertility. This work reviews the disease process from theories regarding origin to the molecular basis for disease sequelae. A thorough understanding of the histopathogenesis and pathophysiology of endometriosis is essential to the development of novel diagnostic and treatment approaches for this debilitating condition.»

«The sum consequence
of this differential expression profile is a marked increase in
the locally bioavailable E2 concentration. E2 stimulates the
production of prostaglandin E2, (PGE2) which further stimulates aromatase activity»

«Gene expression profiling of the peritoneum from
subjects with and without endometriosis demonstrated upregulation of matrix metalloproteinase MMP-3 during the
luteal phase and up-regulation of ICAM-1, transforming
growth factor-beta (TGF-β), and interleukin-6 (IL-6) during
the menstrual phase »

«Endometrial MMP-7 expression is normally suppressed by P during the secretory phase, yet endometriotic lesions exhibit persistent expression of MMP-7 during this phase»

«Other cytokines or chemokines found to be increased in the peritoneal fluid of
patients with endometriosis include macrophage migration
inhibitory factor (80), TNF-α (81), IL-1β, IL-6 (82), IL-8, regulated on activation normal T expressed and secreted»
Organism: Humans
Notable Magnitude of Effect.
#Animals, Cell Adhesion, Cell Survival, Endometriosis / etiology*, Endometriosis / pathology, Endometriosis / physiopathology, Endometrium / pathology, Extramural, Female, Humans, Inflammation / complications, Linda C Giudice, MEDLINE, N.I.H., NCBI, NIH, NLM, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, Neovascularization, PMC3836682, Physiologic, PubMed Abstract, Research Support, Review, Richard O Burney, doi:10.1016/j.fertnstert.2012.06.029, pmid:22819144more...
pubmed.ncbi.nlm.nih.gov/22819144
10.1016/j.fertnstert.2012.06.029

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