9.4
ValidityScore
Valid or Invalid?
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2021Human Cells
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Chen X, Li J, Liu H, Wang L, Wang R, Wu S, Yang T, Yang X, Zhao Y -
«BBR promotes M2-polarized Mφs when H. pylori infection. The anti-inflammatory properties of BBR tightly related to M1-polarized Mφs inhibition and M2-polarized Mφs promotion. BBR activates IL-4-STAT6 signaling pathway, which is crucial exceedingly in M2 Mφs activation and anti-inflammatory response.»
«The M1-specific markers (TNF-α and IFN-γ) in supernatants were reduced significantly and M2
specific markers (TGF-β and IL-10) were increased obviously under BBR intervention. » - Organism: In vitro
- Notable Magnitude of Effect.
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#Animals, Atrophic / drug therapy*, Atrophic / etiology, Atrophic / pathology, Berberine / pharmacology*, Gastritis, Gastritis, Gastritis, Gene Expression Regulation, Helicobacter Infections / complications*, Helicobacter Infections / microbiology, Helicobacter pylori / isolation &, Humans, Interleukin-4 / genetics, Interleukin-4 / metabolism*, MEDLINE, Macrophage Activation / drug effects, Macrophage Activation / immunology*, Male, Mice, NCBI, NIH, NLM, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, PubMed Abstract, Rats, Ruilin Wang, STAT6 Transcription Factor / genetics, STAT6 Transcription Factor / metabolism*, Tao Yang, Yanling Zhao, doi:10.1016/j.lfs.2020.118903, pmid:33340526, purification* -
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2020Publications Review
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Fan D, Hao J, Song D -
«In 1967, Subbaiah and Amin reported that berberine
sulfate has an inhibitory effect on the growth of entamoeba
histolytica. Amin also reported the antimicrobial
activity of BBR [5]. BBR shows good efficacy in
controlling cholera in infant rabbit models. It arrests
diarrhea symptoms, prolongs survival time, and prevents
death possibly by hindering the formation of toxin by
Vibrio cholerae [6]. High concentration of BBR can
suppress the growth of Clostridium difficile and bacillus
cereus by inhibiting spore outgrowth [7]. BBR enhances
the antimicrobial effects of azithromycin (AZM) against
Pseudomonas aeruginosa. The synergism of BBR and
AZM not only remarkably decreases the production of
virulence factors but also suppresses the inflammatory
response by reducing IL-6 and IL-8 and inducing IL-10
[8]. The inflammatory response elicited by V. cholerae and
Escherichia coli can be inhibited by administering BBR in
a rabbit ligated intestinal loop model. Furthermore, BBR
suppresses the inflammatory response to heat-labile
enterotoxin and heat-stable enterotoxin [9]. Berberine is
an antimicrobial drug efficient for treating Eberthella
typhosa infection because it blocks DNA replication with
low cell toxicity [10]. In addition, BBR derivatives exert
bactericidal activities against methicillin-resistant Staphylococcus aureus and enteroinvasive E. coli. BBR facilitates
the nuclear translocation of transcription factor EB (TFEB)
and enhances TFEB-dependent bactericidal activity [11].
Inhibiting secretion and peristalsis
Berberine shows antidiarrheal pharmacological properties
in infant rabbit models of cholera at least in part due to the
BBR suppression of intestinal peristalsis [6]. The antidiarrheal activity of BBR is involved in the inhibition of
myoelectric activity and delay of the small intestine transit
partly by regulating opioid and α-adrenergic receptors
[12]. In addition, BBR inhibits electrogenic ion transport in
rat colonic epithelia, significantly attenuating the short
circuit current responses to mast cell induced by anti-rat
IgE and other agonists that stimulate chloride secretion
[13]. Rabbani has demonstrated the antisecretory activity
of BBR in acute diarrhea caused by enterotoxigenic E. coli
and V. cholerae in a randomized controlled trial. This trial
also showed that BBR is an effective and safe antisecretory
drug without noted adverse effects [14].» - Condition: with Azithromycin
- Organism: Mixed Organisms
- Notable Magnitude of Effect.
-
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2019Rodents
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Gu P, Shen H, Zhu L -
«Conclusions: Berberine hydrochloride (BBR) has beneficial effects in UC. The possible mechanism of anti-inflammatory response by berberine hydrochloride may involve in the blocking of the IL-6/STAT3/NF-κB signaling pathway. Collectively, these fndings provide evidence that berberine hydrochloride might be a useful herb medicine and serve as a promising novel therapy in the treatment of UC in humans.»
«Berberine hydrochloride pretreatment dose-dependently
induced the mRNA expression of IL-4 and IL-10. » - Organism: Mouse / Rat (Rodents)
- Notable Magnitude of Effect.
-
#Animal, Animals, Anti-Inflammatory Agents / pharmacology, Anti-Inflammatory Agents / therapeutic use*, Berberine / pharmacology, Berberine / therapeutic use*, Colitis, Colitis, Colitis, Cytokines / immunology, Dextran Sulfate, Disease Models, Hong Shen, Lei Zhu, MEDLINE, Male, NCBI, NF-kappa B / immunology, NIH, NLM, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, PeiQing Gu, PubMed Abstract, Rats, STAT3 Transcription Factor / immunology, Ulcerative / chemically induced, Ulcerative / drug therapy*, Ulcerative / immunology, Wistar, doi:10.1016/j.intimp.2018.12.036, pmid:30743078 -
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2018
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Aboutaleb N, Maleki SN, Souri F -
«These findings confirm the validity of berberine as a potent anti-inflammatory agent in treatment of ischemic stroke.»
«Berberine (BBR) inhibits cell invasion by suppressing TNF-α-induced MMP-9 in human breast cancer (Kim,
Choi et al. 2008). »
«We found that focal cerebral ischemia increased IL-10 expression (200pikel/um) compared to
control animals (less of 100 pikel/um), whereas berberine dramatically elevated IL-10 levels
more than both control and ischemia groups (270 pikel/um), again confirming potent antiinflammatory effects of berberine.» -
#Animals, Anti-Inflammatory Agents / pharmacology, Antioxidants / pharmacology, Berberine / pharmacology*, Brain / drug effects*, Brain Ischemia / pathology*, Faramarz Souri, MEDLINE, Male, NCBI, NIH, NLM, Nahid Aboutaleb, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, Neuroprotective Agents / pharmacology*, Non-U.S. Gov', PMC5812778, PubMed Abstract, Rats, Rats, Research Support, Solmaz Nasseri Maleki, Wistar, doi:10.1016/j.jchemneu.2017.04.008, pmid:28495517, t -
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