«RESULTS: The serum level of IL-1β, IL-6, and TNF-α is significantly higher in women with endometriosis compared to women free of disease, from the control group (mean 10.777, 183.027, and 131.326, respectively, compared to 3.039, 70.043, and 75.285, respectively; p = 0.002, p < 0.001, and p = 0.015, respectively). No significant differences in the serum levels of IL-5 and IL-12 were observed between the studied groups, and IL-7 had a very low detection rate.
In the present study we found that in women with endometriosis there is a significantly higher serum level of IL-1β, IL-6, and TNF-α, compared to healthycontrols. We
also found that IL-5 and IL-12did not differ significantly
between women with endometriosis and women free of the disease. On the other hand, IL-7 had a very low detection
rate in the studied groups, so we were unable to draw any conclusions regarding its implication.
At this moment, there are a large number of studies
that support the pathophysiological implication of pro-inflammatory and anti-inflammatory cytokines such as IL-2, IL-4, IL-6, IL-8, IL-10, interferon γ (IFN-γ), and TNF-α in endometriosis [14, 15].