Endometriosis positively correlates with TNF-α

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Endometriosis positively correlates with TNF-α
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5.3
TNF-α positively correlates with Endometriosis

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2015

Cohort

Pro-inflammatory cytokines for evaluation of inflammatory status in endometriosis
Andrei M. Malutan, Carmen Bucuri, Dan Mihu, Maria P. Rada, Nicolae Costin, Razvan Ciortea, Tudor Drugan
«RESULTS: The serum level of IL-1β, IL-6, and TNF-α is significantly higher in women with endometriosis compared to women free of disease, from the control group (mean 10.777, 183.027, and 131.326, respectively, compared to 3.039, 70.043, and 75.285, respectively; p = 0.002, p < 0.001, and p = 0.015, respectively). No significant differences in the serum levels of IL-5 and IL-12 were observed between the studied groups, and IL-7 had a very low detection rate.

CONCLUSIONS: Women with endometriosis have elevated levels of key pro-inflammatory cytokine, i.e. IL-1β, IL-6, and TNF-α. At the same time, IL-1β and IL-6 could be used as predictors for endometriosis.»

In the present study we found that in women with endometriosis there is a significantly higher serum level of
IL-1β, IL-6, and TNF-α, compared to healthy controls. We
also found that IL-5 and IL-12 did not differ significantly
between women with endometriosis and women free of the
disease. On the other hand, IL-7 had a very low detection
rate in the studied groups, so we were unable to draw any
conclusions regarding its implication.
At this moment, there are a large number of studies
that support the pathophysiological implication of pro-inflammatory and anti-inflammatory cytokines such as IL-2,
IL-4, IL-6, IL-8, IL-10, interferon γ (IFN-γ), and TNF-α in
endometriosis [14, 15].
Organism: Humans
Notable Magnitude of Effect.
#cytokine, endometriosis, inflammation, interleukin
ncbi.nlm.nih.gov/pmc/articles/PMC4472546
10.5114/ceji.2015.50840

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2.9
Endometriosis positively correlates with IL-1β
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6.2
Endometriosis positively correlates with IL-6
2.1
Endometriosis positively correlates with TNF-α
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2.1
Endometriosis does not affect IL-12
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1.9
Endometriosis does not affect IL-5
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2.1
IL-1β is a biomarker of Endometriosis
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2.1
IL-6 is a biomarker of Endometriosis
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Endometriosis positively correlates with TNF-α
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