«RESULTS: The serum level of IL-1β, IL-6, and TNF-α is significantly higher in women with endometriosis compared to women free of disease, from the control group (mean 10.777, 183.027, and 131.326, respectively, compared to 3.039, 70.043, and 75.285, respectively; p = 0.002, p < 0.001, and p = 0.015, respectively). No significant differences in the serum levels of IL-5 and IL-12 were observed between the studied groups, and IL-7 had a very low detection rate.
In the present study we found that in women with endometriosis there is a significantly higher serum level of IL-1β, IL-6, and TNF-α, compared to healthycontrols. We
also found that IL-5 and IL-12did not differ significantly
between women with endometriosis and women free of the disease. On the other hand, IL-7 had a very low detection
rate in the studied groups, so we were unable to draw any conclusions regarding its implication.
At this moment, there are a large number of studies
that support the pathophysiological implication of pro-inflammatory and anti-inflammatory cytokines such as IL-2, IL-4, IL-6, IL-8, IL-10, interferon γ (IFN-γ), and TNF-α in endometriosis [14, 15].
«Abstract: Originally described over three hundred years ago, endometriosis is classically defined by the presence of endometrial glands and stroma in extrauterine locations. Endometriosis is an inflammatory, estrogen-dependent condition associated with pelvic pain and infertility. This work reviews the diseaseprocess from theories regarding origin to the molecular basis for disease sequelae. A thorough understanding of the histopathogenesis and pathophysiology of endometriosis is essential to the development of novel diagnostic and treatment approaches for this debilitating condition.»
«The sum consequence
of this differential expression profile is a marked increase in
the locally bioavailable E2concentration. E2stimulates the
production of prostaglandinE2, (PGE2) which further stimulatesaromatase activity»
«Gene expression profiling of the peritoneum from
subjects with and without endometriosis demonstrated upregulation of matrix metalloproteinaseMMP-3 during the
luteal phase and up-regulation of ICAM-1, transforming
growth factor-beta (TGF-β), and interleukin-6 (IL-6) during
the menstrual phase »
«Endometrial MMP-7 expression is normally suppressed by P during the secretory phase, yet endometriotic lesions exhibit persistent expression of MMP-7 during this phase»
«Other cytokines or chemokines found to be increased in the peritoneal fluid of patients with endometriosis include macrophage migration
inhibitory factor (80), TNF-α (81), IL-1β, IL-6 (82), IL-8, regulated on activation normal T expressed and secreted»