L. plantarum DR7 suppresses TNF-α

Lactobacillus plantarum DR7 suppresses TNF-α

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2019

RCT

Lactobacillus plantarum DR7 alleviates stress and anxiety in adults: a randomised, double-blind, placebo-controlled study
Abdullah MFIL, Choi SB, Chong HX, Hor YY, Jaafar MH, Lew LC, Liong MT, Ong KL, Park YH, Wahid N, Yusoff MSB, Yusoff NAA, Zakaria N
«Abstract: Probiotic have been reported to exert beneficial effects along the gut-brain axis. This randomised, double-blind and placebo-controlled human study aimed to evaluate such properties of Lactobacillus plantarum DR7 ( l. plantarum dr7, ) and its accompanying mechanisms in stressed adults. One hundred and eleven (n=111; DR7 n=56, placebo n=55) stressed adults were recruited based on moderate stress levels using the PSS-10 questionnaire. The consumption of DR7 (1×10⁹ cfu/day) for 12 weeks reduced symptoms of stress (P=0.024), anxiety (P=0.001), and total psychological scores (P=0.022) as early as 8 weeks among stressed adults compared to the placebo group as assessed by the DASS-42 questionnaire. Plasma cortisol level was reduced among DR7 subjects as compared to the placebo, accompanied by reduced plasma pro-inflammatory cytokine, such as interferon-γ ( IFN-γ ) and transforming growth factor-α (tgfα) and increased plasma anti-inflammatory cytokines, such as interleukin 10 ( il-10 ) (P<0.05). DR7 better improved cognitive and memory functions in normal adults (>30 years old), such as basic attention, emotional cognition, and associate learning (learning performance)(P<0.05), as compared to the placebo and young adults (<30 years old). The administration of DR7 enhanced the serotonin pathway, as observed by lowered expressions of plasma dopamine β-hydroxylase (DBH), tyrosine hydroxylase (TH), indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase accompanied by increased expressions of tryptophan hydroxylase-2 and 5-hydroxytryptamine receptor-6, while stabilising the dopamine pathway as observed via stabilised expressions of TH and DBH over 12 weeks as compared to the placebo (P<0.05). Our results indicated that DR7 fulfil the requirement of a probiotic strain as per recommendation of FAO/WHO and could be applicable as a natural strategy to improve psychological functions, cognitive health and memory in stressed adults.»

The administration of DR7 significantly reduced plasma
cortisol levels in total subjects compared to the placebo
group after 12 weeks (P=0.008) (Figure 7), accompanied
by reduced plasma pro-inflammatory cytokine in the DR7
group as compared to the placebo group, such as IFN-γ
(P<0.001) and TNF-α (P=0.006), and increased plasma antiinflammatory cytokines IL-10 (P=0.035) (Figure 7C). The
administration of DR7 benefited both the young and normal
adult groups differently. DR7 exerted more prevalent effects
in increasing plasma anti-inflammatory cytokines IL-10
(P=0.033) and decreasing pro-inflammatory cytokine
IFN-γ (P=0.015) in young adults compared to the placebo
over 12 weeks (Figure 7A), while only decreasing plasma
pro-inflammatory cytokine IFN-γ (P<0.001), TNF-α
(P=0.003) and IL-1β (P=0.002) in normal adults compared
to the placebo over 12 weeks without any effect on proinflammatory cytokines (Figure 7B).
Organism: Humans
Notable Magnitude of Effect.
#Adult, Anxiety / microbiology, Anxiety / prevention &, Anxiety / psychology, Cognition / physiology, Cytokines / blood, Double-Blind Method, H X Chong, Humans, Hydrocortisone / blood, Lactobacillus plantarum / physiology*, M-T Liong, MEDLINE, Memory / physiology, Middle Aged, N A A Yusoff, NCBI, NIH, NLM, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, Neurotransmitter Agents / blood, Probiotics / administration &, Psychological / microbiology, Psychological / psychology, Psychological / therapy*, PubMed Abstract, Randomized Controlled Trial, Serotonin / blood, Stress, Treatment Outcome, Young Adult, control*, doi:10.3920/BM2018.0135, dosage*, pmid:30882244more...
pubmed.ncbi.nlm.nih.gov/30882244
10.3920/BM2018.0135

From this research we know that
3.1
Lactobacillus plantarum DR7 reduces Cortisol
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2.9
Lactobacillus plantarum DR7 enhances Serotonin pathway
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2.9
L. plantarum DR7 increases expression of Tryptophan Hydroxylase-2
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3.1
Lactobacillus plantarum DR7 increases expression of 5-HT6 Receptor
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2.9
Lactobacillus plantarum DR7 decreases expression of TDO
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2.9
L. plantarum DR7 decreases expression of Indoleamine 2,3-Dioxygenase
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3.1
L. plantarum DR7 decreases expression of Dopamine Β-Hydroxylase
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3.1
Lactobacillus plantarum DR7 decreases expression of Tyrosine Hydroxylase
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3.1
Lactobacillus plantarum DR7 improves Attention
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3.1
Lactobacillus plantarum DR7 improves Learning performance
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3.1
Lactobacillus plantarum DR7 improves Cognition
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5.3
Lactobacillus plantarum DR7 enhances IL-10
5.3
Lactobacillus plantarum DR7 suppresses TNF-α
5.3
Lactobacillus plantarum DR7 suppresses IFN-γ
3.1
Lactobacillus plantarum DR7 reduces Anxiety
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3.1
Lactobacillus plantarum DR7 reduces IFN-γ
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3.1
Lactobacillus plantarum DR7 reduces Stress
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2019

RCT

Lactobacillus plantarum DR7 improved upper respiratory tract infections via enhancing immune and inflammatory parameters: A randomized, double-blind, placebo-controlled study
A. Yusoff, Hui-Xian Chong, Kee-Leong Ong, Lee-Ching Lew, Min-Tze Liong, Mohamad Hafis Jaafar, Mohammad Farris I.L. Abdullah, Muhamad S.B. Yusoff, Normala Wahid, Norzila Zakaria, Nur Asmaa', Sy-Bing Choi, Yan-Yan Hor, Yong-Ha Park
«The aims of this study were to investigate the effects of Lactobacillus plantarum DR7 isolated from bovine milk against upper respiratory tract infections (URTI) and elucidate the possible mechanisms underlying immunomodulatory properties. The DR7 strain (9 log cfu/d) was administered for 12 wk in a randomized, double-blind, and placebo-controlled human study involving 109 adults (DR7, n = 56; placebo, n = 53). Subjects were assessed for health conditions monthly via questionnaires, and blood samples were evaluated for cytokine concentration, peroxidation and oxidative stress, and gene expression in T cell and natural killer (NK) cell. The administration of DR7 reduced the duration of nasal symptoms (mean difference 5.09 d; 95% CI: 0.42–9.75) and the frequency of URTI (mean difference 0.32; 95% CI: 0.01–0.63) after 12 and 4 wk, respectively, compared with the placebo. The DR7 treatment suppressed plasma proinflammatory cytokines (IFN-γ, TNF-α) in middle-age adults (30 to 60 yr old), while enhancing anti-inflammatory cytokines (IL-4, IL-10) in young adults (<30 yr old), accompanied by reduced plasma peroxidation and oxidative stress levels compared with the placebo. Young adults who received DR7 showed higher expression of plasma CD44 and CD117 by 4.50- and 2.22-fold, respectively, compared with the placebo. Meanwhile, middle-age adults showed lower expression of plasma CD4 and CD8 by 11.26- and 1.80-fold, respectively, compared with the placebo, indicating less T-cell activation. In contrast, both young and middle-age adults who received DR7 showed enhanced presence of nonresting and mature NK cell compared with those who received the placebo. We postulate that DR7 alleviated the symptoms of URTI by improving inflammatory parameters and enhancing immunomodulatory properties.»
Condition: in middle-aged adults (30 to 60 yr old)
Organism: Humans
Notable Magnitude of Effect.
#Lactobacillus plantarum DR7, T cells, mucosal integrity, natural killer cells, upper respiratory tract infection
sciencedirect.com/science/article/pii/S0022030219303169
10.3168/jds.2018-16103

From this research we know that
5.3
Lactobacillus plantarum DR7 enhances IL-10
5.3
Lactobacillus plantarum DR7 suppresses TNF-α
5.3
Lactobacillus plantarum DR7 suppresses IFN-γ
2.9
Lactobacillus plantarum DR7 enhances NK cell
(BioMindmap Proof Quality is Acceptable.)
3.1
Lactobacillus plantarum DR7 decreases expression of CD4+ T-cells
(BioMindmap Proof Quality is Acceptable.)
3.1
Lactobacillus plantarum DR7 decreases expression of CD8+ T-cells
(BioMindmap Proof Quality is Acceptable.)
2.9
Lactobacillus plantarum DR7 enhances expression of CD44
(BioMindmap Proof Quality is Acceptable.)
2.9
Lactobacillus plantarum DR7 enhances expression of CD117
(BioMindmap Proof Quality is Acceptable.)
2.9
Lactobacillus plantarum DR7 enhances IL-4
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3.1
Lactobacillus plantarum DR7 improves URTI
(BioMindmap Proof Quality is Acceptable.)

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