9.6
ValidityScore
Valid or Invalid?
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2013Cohort
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Becker KG, Bernier M, Blouin MJ, Bohr VA, Gomes AP, Ingram DK, Martin-Montalvo A, Mercken EM, Minor RK, Mitchell SJ, Mote PL, Palacios HH, Pollak M, Scheibye-Knudsen M, Schwab M, Sinclair DA, Spindler SR, Ward TM, Wolf NS, Yu Y, Zhang Y, de Cabo R - Dose: 0.1% w/w in diet
- Organism: Mouse / Rat (Rodents)
- Found At: https://nestarenie.ru/metformin.html
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#AMP-Activated Protein Kinases, Alejandro Martin-Montalvo, Animals, Antioxidants / pharmacology, Biomarkers / blood, Caloric Restriction, Electron Transport / drug effects, Enzyme Activation / drug effects, Evi M Mercken, Health*, Inbred C57BL, Inflammation / blood, Inflammation / drug therapy, Inflammation / pathology, Intramural, Longevity / drug effects*, MEDLINE, Male, Metformin / pharmacology*, Metformin / therapeutic use, Mice, Mice, Mitochondria / drug effects, Mitochondria / metabolism, N.I.H., NCBI, NIH, NLM, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, Non-U.S. Gov', PMC3736576, PubMed Abstract, Rafael de Cabo, Research Support, Research Support, Survival Analysis, Transcriptome / drug effects, Transcriptome / genetics, doi:10.1038/ncomms3192, pmid:23900241, t -
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2014Cohort
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Billen J, Braeckman BP, De Haes W, Depuydt G, Frooninckx L, Schoofs L, Smolders A, Temmerman L, Van Assche R -
"We show that metformin extends lifespan through the process of mitohormesis and propose a signaling cascade in which metformin-induced production of reactive oxygen species increases overall life expectancy."
- Organism: Humans
- Found At: https://nestarenie.ru/metformin.html
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#Acyl-CoA Dehydrogenase / metabolism, Amino Acids, Animal, Animals, Branched-Chain / chemistry, Caenorhabditis elegans / drug effects*, Caenorhabditis elegans / metabolism, Caenorhabditis elegans Proteins / physiology*, Extramural, Gene Expression Regulation, Green Fluorescent Proteins / chemistry, Hormesis / drug effects*, Hot Temperature, Hydrogen Peroxide / chemistry, Hypoglycemic Agents / pharmacology*, Liesbet Temmerman, Longevity / drug effects*, Lotte Frooninckx, MEDLINE, Metformin / pharmacology*, Mitochondria / enzymology, Models, N.I.H., NCBI, NIH, NLM, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, Non-U.S. Gov', Oxidative Stress, Oxygen Consumption, PMC4066537, Peroxiredoxins / physiology*, Protein Unfolding, Proteomics, PubMed Abstract, Reactive Oxygen Species, Research Support, Research Support, Rotenone / chemistry, Signal Transduction, Time Factors, Wouter De Haes, doi:10.1073/pnas.1321776111, pmid:24889636, t -
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2013Publications Review
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Anisimov VN -
«Antidiabetic biguanides such as metformin, which reduce hyperglycemia and hyperinsulinemia by decreasing insulin resistance, extend lifespan, and inhibit carcinogenesis in rodents. »
- Organism: Mouse / Rat (Rodents)
- Found At: https://nestarenie.ru/metformin.html
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#Aging / drug effects*, Aging / genetics, Aging / metabolism, Animals, Carcinogenesis / drug effects*, Carcinogenesis / genetics, Carcinogenesis / metabolism, Humans, Hyperglycemia / metabolism, Hyperglycemia / prevention &, Hyperinsulinism / metabolism, Hyperinsulinism / prevention &, Hypoglycemic Agents / pharmacology*, Hypoglycemic Agents / therapeutic use, Insulin / metabolism, Insulin Resistance, Insulin-Like Growth Factor I / metabolism, Longevity / drug effects, Longevity / genetics, MEDLINE, Metformin / pharmacology*, Metformin / therapeutic use, NCBI, NIH, NLM, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, Non-U.S. Gov', PMC3906334, PubMed Abstract, Research Support, Review, Vladimir N Anisimov, control, control, doi:10.4161/cc.26928, pmid:24189526, t -
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2011Cohort
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Anisimov VN, Berstein LM, Egormin PA, Kovalenko IG, Piskunova TS, Popovich IG, Poroshina TE, Semenchenko AV, Tyndyk ML, Yurova MN, Zabezhinski MA - Organism: Humans
- Comments: the treatment started at the age of 15 months failed to increase life span
- Found At: https://nestarenie.ru/metformin.html
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#Age Factors, Animals, Body Temperature, Body Weight, Drinking, Eating, Estrous Cycle / drug effects, Estrous Cycle / physiology, Female, Humans, Hypoglycemic Agents / pharmacology*, Lev M Berstein, Life Expectancy*, Longevity / drug effects*, MEDLINE, Metformin / pharmacology*, Mice, NCBI, NIH, NLM, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, Neoplasms / pathology, Neoplasms / prevention &, Non-U.S. Gov', PMC3082009, PubMed Abstract, Research Support, Tatiana E Poroshina, Vladimir N Anisimov, control*, doi:10.18632/aging.100273, pmid:21386129, t -
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2011Cohort
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Anisimov VN, Berstein LM, Egormin PA, Kovalenko IG, Piskunova TS, Popovich IG, Poroshina TE, Semenchenko AV, Tyndyk ML, Yurova MN, Zabezhinski MA - Organism: Humans
- Comments: the treatment started at the age of 15 months failed to increase life span.
- Found At: https://nestarenie.ru/metformin.html
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#Age Factors, Animals, Body Temperature, Body Weight, Drinking, Eating, Estrous Cycle / drug effects, Estrous Cycle / physiology, Female, Humans, Hypoglycemic Agents / pharmacology*, Lev M Berstein, Life Expectancy*, Longevity / drug effects*, MEDLINE, Metformin / pharmacology*, Mice, NCBI, NIH, NLM, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, Neoplasms / pathology, Neoplasms / prevention &, Non-U.S. Gov', PMC3082009, PubMed Abstract, Research Support, Tatiana E Poroshina, Vladimir N Anisimov, control*, doi:10.18632/aging.100273, pmid:21386129, t -
ranked
added it
1 week ago
on Sep 13, 2020