« However, it must be taken into account that polysaccharides  contained in Spirulina (Table 1) can induceNF-kBpathway. In particular, the high molecular weight polysaccharide Immulina has been reported have immunostimulatory activity [70–72] and increasedIL-1β and TNF-α expression by inducing NF-kappa B pathway . Despite the fact that the immunostimulatory activity could increaseinflammation, it must be taken into account that in syngeneic tumor-implant mice (C57BL/6 versus B16 melanoma) the antitumor activity and the increased NK cytotoxicity were observed in parallel with the production of interferon-gamma (IFN-γ) . Furthermore, it was also observed that Spirulina consumption increasedmacrophage activation (phagocytic activity and nitrite production) in chicken . Therefore, Spirulina could modulateimmune function, reducing inflammation without inhibiting the innate immune defences.»
«Spirulina may ameliorateanemia and immunosenescence in older subjects. We encourage large human studies to determine whether this safe supplement could prove beneficial in randomized clinical trials.»
6 tablets of 500 mg Spirulina per day for a 12-week period
Condition: 40 volunteers of both sexes with an age of 50 years or older who had no history of major chronic diseases
Comments:"Older women appeared to benefit more rapidly from Spirulinasupplements"