Hu et al.  suggested a potential concerted modulation of nuclear factor-erythroid 2-related factor 2 (Nfr2)/antioxidant responsive elements (ARE) and nuclear factor-kappa B (NF-kB) in inflammation and carcinogenesis. Many phenolic antioxidant [52, 53] and C-phycocyanin [54, 55] exert their anti-inflammatory and antioxidanteffects through the integrated modulation of Nrf2 and NF-kBpathways. In particular, C-phycocyanin was able to inhibitNF-kB  and inducedNrf2 activation in pancreatic β-cell INS-1 . Although Spirulinaantioxidant and anti-inflammatory activities can be due to both phenolic compounds and phycocyanins, C-phycocyanin is contained in higher amounts (Table 1) and has been studied more in vitro [56–63] and in animal models [27, 57, 64–66]..»
"Decreasedinflammation via this route might have decreased the production of superoxide, hydrogen peroxide, and hypochlorous acid by the activated neutrophils (10) leading to less lipid peroxidation after spirulina supplementation."
«Abstract: Spirulina is a photosynthetic, filamentous, spiral-shaped and multicellular edible microbe. It is the nature's richest and most complete source of nutrition. Spirulina has a unique blend of nutrients that no single source can offer. The alga contains a wide spectrum of prophylactic and therapeutic nutrients that include B-complex vitamins, minerals, proteins, gamma-linolenic acid and the super anti-oxidants such as beta-carotene, vitamin E, trace elements and a number of unexplored bioactive compounds. Because of its apparent ability to stimulate whole human physiology, Spirulina exhibits therapeutic functions such as antioxidant, anti-bacterial, antiviral, anticancer, anti-inflammatory, anti-allergic and anti-diabetic and plethora of beneficial functions. Spirulina consumption appears to promote the growth of intestinal micro flora as well. The review discusses the potential of Spirulina in health care management.»