Vitamin D
deficiency decreases
Bone mineral density
Vitamin D
deficiency decreases
Bone mineral density
5.0
ValidityScore
Valid or Invalid?
«vitamin D deficiency, especially in young animals, produces osteomalacia, defined as a defect in bone mineralization. Both osteoporosis and osteomalacia compromise the strength of bone and in humans increase the risk of fracture»
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2010Publications Review
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Howard A. Morris, Paul H. Anderson, Peter D. O’Loughlin -
«CONCLUSIONS: Studies in animals have identified that feeding low levels of dietary calcium produces a negative calcium balance and gross bone loss. The calcium requirement in the estrogen deficient state is markedly increased and therefore the combination of calcium deficiency and oophorectomy enhances overall bone loss. In the context of vitamin D and dietary calcium depletion, osteomalacia occurs only when both vitamin D and dietary calcium levels are reduced and osteoporosis occurs with either a low calcium diet in the presence of adequate vitamin D or when vitamin D status is low in the presence of adequate dietary calcium. Maximum bone architecture and strength is only achieved when an adequate vitamin D status is combined with sufficient dietary calcium to achieve a positive calcium balance. Each of the major bone cell, osteoblasts, osteoclasts and osteocytes are capable of metabolizing 25D to 1,25D to elicit biological activities including reduction of bone resorption by osteoclasts and to enhance maturation and mineralization by osteoblasts and osteocytes. Thus optimal bone health is only achieved when the vitamin D status is improved thus providing adequate levels of the circulating pro-hormone 25D for local metabolism by bone cell into the active hormone 1,25D. Each of these bone cell activities is consistent with the actions of adequate circulating levels of 25D observed in vivo and with clinical outcomes from vitamin D and calcium dietary supplementation.»
- Organism: Mixed Organisms
- Strong Magnitude of Effect.
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ranked
added it
1 year ago
on Jul 12, 2020