Lycopene
decreases
Testosterone
Lycopene
decreases
Testosterone
7.0
ValidityScore
Valid or Invalid?
Sham-operated rats provided with either phytofluene, lycopene, or tomato powder had approximately 40-50% lower serum testosterone concentration than the sham-operated, control-fed group.
-
2015
-
Erika Enk Rueter, Larisa Nonn, Misop Han, Peter H. Gann, Richard B. van Breemen, Ryan J. Deaton, Viju Ananthanarayanan, Virgilia Macias -
Participants consumed placebo or tomato extract capsules containing 30 mg/day lycopene.
Results
58 men completed the trial. Serum lycopene increased 0.55 μmol/L with treatment and declined 0.29 μmol/L with placebo. We observed no meaningful differences in PSA, IGF-1 or IGFBP3 concentration between groups, nor any differences in expression of MCM-2 or p27 in epithelial nuclei. Prevalences of cancer, HGPIN, atrophy or inflammation post-treatment were similar; however, more extensive atrophy and less extensive HGPIN was more common in the lycopene group. -
-
2014
-
Dennis K. Pearl, Hsueh-Li Tan, Jennifer M. Thomas-Ahner, John W. Erdman, Jr., Lei Wan, Nancy E. Moran, Steven K. Clinton -
Consumption of tomato products containing the carotenoid lycopene is associated with a reduced risk of prostate cancer.
Expression of genes involved in androgen metabolism/signaling pathways are reduced by lycopene feeding (Srd5a1) and by tomato-feeding (Srd5a2, Pxn, and Srebf1). Additionally, tomato-feeding significantly reduced expression of genes associated with stem cell features, Aldh1a and Ly6a, while lycopene-feeding significantly reduced expression of neuroendocrine differentiation-related genes, Ngfr and Syp. Collectively, these studies demonstrate a profile of testosterone-regulated genes associated with early stages of prostate carcinogenesis that are potential mechanistic targets of dietary tomato components. -
-
2014
-
Aamir Ahmad, Bin Bao, Dejuan Kong, Fazlul H. Sarkar, Yiwei Li -
Experimental studies have revealed that lycopene could down-regulate the expression of Ras, NF-κB, cyclin D, p-Akt, and Bcl-2, and up-regulate the expression of p21, p27, p53, and Bax in PCa cell [74], demonstrating that lycopene modulates the signaling that controls cell growth and apoptotic cell death pathways. Lycopene also inhibited IGF-I signal transduction in normal prostate epithelial cell through down-regulation of DHT-stimulated IGF-1 production [75]. Lycopene also showed the inhibitory effects on AR signaling in PCa. One study showed that lycopene could inhibit the activity of AR gene element and the AR expression in a dose-dependent manner [76]. Consistent with AR inhibition, the suppression of PSA expression by lycopene was also observed, suggesting that dietary lycopene could have clinical impact in PCa.
-
-
2010
-
Zhang X, et al. -
The addition of 0.5 micromol/L, 5 micromol/L, 10 micromol/L and 15 micromol/L of lycopene was shown to inhibit cell growth by 2.66%, 4.29%, 3.73% and 13.66%, respectively, compared with the THF solvent control samples (P=0.015). As compared with the RPMI1640 medium group, cell proliferation in the presence of 5 micromol/L, 10 micromol/L, and 15 micromol/L lycopene was inhibited by 8.12%, 6.33% and 12.00%, respectively (P=0.024). We showed for the first time that lycopene inhibited the activity of the androgen receptor gene element in a dose-related manner. Inhibition was seen in the transcription of the luciferase construct and confirmed by androgen receptor element expression assayed by Western blotting. Regression slopes of (log) PSA vs. time decreased in 26/37 (70%, 95%CI 53%-84%) of the patients after supplementation and in eight cases (21%) the post-treatment slope was negative. For these eight patients, the average fall in PSA was equivalent to 2% over 28 days (i.e. an average slope/d of -0.000713). The Wilcoxon rank-sum test showed an overall statistically significant decrease in slope (P=0.0007). Analysis of the PSA doubling time (pretreatment vs. posttreatment) showed a median increase after supplementation for 174 days; however, this was not statistically significant (P=0.18).
Keywords: Age;Age, 80 and over;Antioxidants;Blotting, Western;Carotenoids;Cell Line, Tumor;Dietary Supplements;Furans;Gene Expression Regulation;Humans;Male;Microscopy, Fluorescence;Middle Age;Pilot Projects;Prostate-Specific Antigen;Prostatic Neoplasms;Receptors, Androgen -
-
2008
-
Liu X, et al. -
Dihydrotestosterone (DHT) stimulates insulin-like growth factor-I (IGF-I) production.
Lycopene consumption is inversely related to human prostate cancer risk and inhibits IGF-I and androgen signaling in rat prostate cancer. In this study, lycopene, in dietary concentration, reversed DHT effects of 6S cell on NPE cell death, decreased 6S cell IGF-I production by reducing AR and beta-catenin nuclear localization and inhibited IGF-I-stimulated NPE and PREC growth, perhaps by attenuating IGF-I's effects on serine phosphorylation of Akt and GSK3beta and tyrosine phosphorylation of GSK3. T
Keywords: Adult;Carotenoids;Cell Division;Cell, Cultured;Coculture Techniques;Epithelial Cell;Humans;Insulin-Like Growth Factor I;Male;Prostate;Prostatic Neoplasms;Signal Transduction;Stromal Cell;Tumor Cell, Cultured -
-
2006
-
Campbell JK, et al. -
Sham-operated rats provided with either phytofluene, lycopene, or tomato powder had approximately 40-50% lower serum testosterone concentration than the sham-operated, control-fed group. Tissue and serum phytofluene and lycopene concentration were greater in castrated rats than in sham-operated rats, which may have been due in part to a decrease of hepatic CYP 3A1 mRNA expression and benzyloxyresorufin-O-dealkylase activity.
Keywords: 17-Hydroxysteroid Dehydrogenases;Animals;Aryl Hydrocarbon Hydroxylases;Carotenoids;Cytochrome P-450 CYP2B1;Cytochrome P-450 CYP3A;Dihydrotestosterone;Fatty Acid Binding Protein 3;Fatty Acid-Binding Proteins;Male;PPAR gamma;Prostate;RNA, Messenger;Rats;Rats, Inbred F344;Testis;Testosterone -
ranked
added it
4 years ago
on Aug 12, 2018