Huperzine-A is a natural sesquiterpene alkaloid compound extracted from Huperzia Serrata (Chinese herb) which acts a reversible acetylcholinesterase (enzyme that break downs acetylcholine) inhibitor by crossing blood-brain barrier.

Huperzine-A has stronger penetration in blood brain barrier, prolonged duration of acetylcholinesterase inhibitory action and greater bioavailability than other cholinesterase inhibitors (donepezil, rivastigmine, and tacrine).

Huperzine-A has cognitive enhancing properties by protecting against several pathological factors inducing neurodegeneration such as beta-amyloid protein (or peptide), ischemia, hydrogen peroxide, glutamate, apoptosis and staurosporine-induced cytotoxicity. As a result, oxidative stress is reduced, expression of apoptotic proteins (Bcl-2, Bax, P53, caspase-3) gets regulated, protection of mitochondria and interference with amyloid precursor protein metabolism occurs, nerve growth factor and its receptors is up-regulated.

Neurogenez ranked added it 9 months ago on May 22, 2020