Calcification
causes
Hypertension
(BioMindmap Proof Quality is Acceptable.)
Calcification
causes
Hypertension
(BioMindmap Proof Quality is Acceptable.)
3.6
ValidityScore
Valid or Invalid?
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Recent studies found a clear association between long-term oral (or intravenous) anticoagulant treatment (OAC) and reduced bone quality due to reduction of active osteocalcin. OAC might lead to an increased incidence of fracture, reduced bone mineral density or content, osteopenia, and increased serum levels of undercarboxylated osteocalcin.
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2012
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Caren M. Gundberg, Jane B. Lian, Sarah L. Booth
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In humans, the percentage of the circulating osteocalcin that is not γ-carboxylated (percent ucOC) is used as a biomarker of vitamin K status. In contrast, when ucOC is not corrected for total osteocalcin, the interpretation of this measure is confounded by osteoblastic activity, independent of vitamin K.
vitamin K decreases ucOC. -
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2009
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Dessa Gemar, Diane Krueger, Jean Engelke, John Suttie, Judith Harke, Mary Checovich, Neil Binkley, Nellie Vallarta-Ast, Richard Chappell
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1999
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Caraballo PJ, et al.
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Oral anticoagulants are putative risk factors for osteoporosis, but observational cross-sectional studies describing their effects on bone mineral density have reported conflicting results, prospective studies are not available, and randomized trials are not feasible.
Keywords: Administration, Oral;Age;Anticoagulants;Bone Density;Cross-Sectional Studies;Female;Femur;Femur Neck;Humans;Lumbar Vertebrae;Male;Middle Age;Radius;Time Factors -
added it
4 years ago
on Aug 6, 2018
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