8.8
ValidityScore
Valid or Invalid?
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2018Publications Review
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Dimitri P Mikhailidis, Maciej Banach, Niki Katsiki -
«CONCLUSIONS: There is evidence linking leptin levels with the presence, severity and/or prognosis of CHD, stroke, PAD, carotid artery disease, CKD and T2DM. Leptin promotes inflammation, thrombosis, arteriosclerosis, angiogenesis and atherosclerosis. Lifestyle measures and several drugs, including statins and antidiabetic drugs, may affect its levels. Further research is needed to establish leptin as a potential therapeutic target.»
- Organism: Humans
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2018Meta-Analysis
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Kazuya Murata, Ryutaro Kaneko, Satoshi Ida -
«RESULTS: A total of 10 RCT met the eligibility criteria and were included in the meta‐analysis. Significantly lower blood leptin levels were observed in the pioglitazone group (standardized mean difference -0.58, 95% confidence interval -1.12 to -0.05%, P = 0.03) than in the placebo group. There was no significant difference in blood leptin levels observed between the pioglitazone and oral antidiabetic drug groups (standardized mean difference -0.01, 95% confidence interval -0.20 to 0.19%, P = 0.93).
CONCLUSIONS: There was a significant difference in blood leptin levels between the pioglitazone and placebo groups. However, relatively few RCT were included in the study, and there was a high level of statistical heterogeneity; we believe that this could have affected the results.» - Organism: Humans
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11 months ago
on May 13, 2020