5.2
ValidityScore
Valid or Invalid?
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2016Systematic Review
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Makoto Ishii, Matthew J. McGuire -
«CONCLUSIONS: The past few years have seen an increased recognition for the role that body weight and systemic metabolism have on the pathobiology of AD. This association highlights the importance that hormone regulating body weight and metabolism such as leptin may have on AD. In this review, we briefly summarized the role of leptin in AD from cellular and animal models to recent human studies. The accumulating evidence from these studies collectively suggests that leptin has a pro-cognitive and neuroprotective role against AD. Furthermore, we propose that leptin has a bidirectional role in AD, where dysfunctional leptin signaling can worsen cognition and increase AD pathology, while worsening AD pathology can in turn cause dysfunctional leptin signaling, which together results in a downward spiral of progressive neurodegeneration and worsening weight loss and metabolic deficits. Therefore, leptin is well positioned to serve as a vital link between body weight/systemic metabolism and AD. While there are many unanswered question that need to be addressed, future studies will help determine whether leptin and leptin signaling pathways will fulfill its potential as a novel drug target and diagnostic tool in AD.»
- Organism: Humans
- Notable Magnitude of Effect.
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ranked
added it
9 months ago
on May 12, 2020