Hyperinsulinemia
decreases
IGFBP-1
(BioMindmap Proof Quality is Low.)
Hyperinsulinemia
decreases
IGFBP-1
(BioMindmap Proof Quality is Low.)
2.1
ValidityScore
Valid or Invalid?
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2011Cohort
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Emilie Friberg -
Hyperinsulinemia has been shown to stimulate the growth of endometrial stromal cell by binding to insulin receptors in endometrium (29) and may also increase levels of free estrogen through decreasing concentration of circulating sex hormone binding globulin (30, 31) and through decreasing levels of IGFBP-1 increase circulating free IGF-1. IGF-1 stimulates cell proliferation by binding and activating IGF-1 receptors in the endometrium (32–37). Estrogen in turn have been shown to increase endometrial cancer risk by stimulating proliferation of endometrial cell (38). Hyperinsulinemia is also associated with hypoadiponectinemia and low levels of adiponectin have been consistently related to higher risk of endometrial cancer (39–42). In our study, the strongest association with sucrose was observed among overweight and obese women, already at a higher risk for endometrial cancer; this observation is consistent with the notion that hypoadiponectinemia, insulin resistance, and hyperinsulinemia may be involved in the process (43–46). Dietary fat can modify the insulinemic response to foods by delaying the gastric emptying and enhancing the insulin response (24). Our results observing the strongest associations among women with a low intake of fat are consistent with this notion.
- Organism: Humans
- Notable Magnitude of Effect.
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ranked
added it
2 years ago
on May 7, 2020