Hesperidin reduces Vascular Cell Adhesion Molecule 1

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Hesperidin reduces VCAM-1

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2019

Systematic Review

The effect of hesperidin supplementation on inflammatory markers in human adults: A systematic review and meta-analysis of randomized controlled cl...
Lorzadeh E, et al.
«RESULTS: Six eligible RCT with 296 participants were included in the systematic review. The meta-analysis revealed that hesperidin significantly reduces Vascular Cell Adhesion Molecule 1 (VCAM-1) levels [weight mean difference (WMD) = -22.81 ng/L, P = 0.041, n = 3]. No considerable changes was observed for serum C-reactive protein (CRP) levels (WMD = -0.69 mg/L, P = 0.079, n = 5); the subgroup analysis showed a significant reduction in studies with a parallel design (WMD = -0.72 mg/L, P = 0.024, n = 3), and studies with more than 4 weeks of follow-up (WMD = -0.76 mg/L, P = 0.020, n = 2). Hesperidin supplementation had no signification effect on circulating E-selectin, interleukin 6, and Intercellular Adhesion Molecule 1 (ICAM-1) levels.

CONCLUSION: The present study suggests that although hesperidin supplementation significantly improves VCAM-1 levels; however, other inflammatory markers might not be affected. Further high-quality systematic reviews exploring the effect of hesperidin particularly on VCAM-1, ICAM-1, E-selectin, and interleukin 6 are still needed to confirm these results.»
Organism: Humans
#Biomarkers, C-Reactive Protein, Cell Adhesion Molecules, Databases, E-Selectin, Factual, Hesperidin, Humans, Inflammation, Interleukin-6, Randomized Controlled Trials as Topicmore...
ncbi.nlm.nih.gov/pubmed/30991044
10.1016/j.cbi.2019.04.016

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