Ginger downregulates TNF-α

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Ginger downregulates TNF-α
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In animal models, Habib et al. [43] showed that ginger extract inhibits liver carcinogenesis in Wistar rat through the downregulation of elevated NF-κB and TNF-α. Thus, ginger may act as an anticancer and anti-inflammatory agent, which could be helpful in prevention and treatment of liver cancer.

Proofs

2015

Ginger and Its Constituents: Role in Prevention and Treatment of Gastrointestinal Cancer
Amit K. Tyagi, Sahdeo Prasad
a significant number of in vitro, in vivo, and epidemiological studies further provide substantial evidence that ginger and its active compounds are effective against wide variety of human diseases including GI cancer.

Ginger has been found to be effective against various GI cancer such as gastric cancer, pancreatic cancer, liver cancer, colorectal cancer, and cholangiocarcinoma.
ncbi.nlm.nih.gov/pmc/articles/PMC4369959
10.1155/2015/142979

From this research we know that
1.6
Ginger downregulates NF-kB
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2.5
Ginger downregulates TNF-α
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2.5
TNF-α increases Inflammation
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2.5
TNF-α excess causes Cancer
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2.5
Ginger inhibits MMP-2
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2.5
Ginger inhibits MMP-9
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1.6
Ginger suppresses MAPK
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1.6
Ginger suppresses PI3K
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1.6
Ginger decreases VEGF
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1.6
Ginger inhibits Cell proliferation
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0.8
Ginger may cure GI cancer
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1.6
Ginger contains Polyphenols
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2013

TNF-α signalling and inflammation: interactions between old acquaintances.
Zelová H and Hošek J
This review concisely summarizes the role of this pro-inflammatory cytokine during inflammation. It is focused mainly on TNF-α intracellular signaling and its influence on the typical inflammatory features in the organism. Being one of the most important pro-inflammatory cytokine, TNF-α participates in vasodilatation and edema formation, and leukocyte adhesion to epithelium through expression of adhesion molecules; it regulates blood coagulation, contributes to oxidative stress in sites of inflammation, and indirectly induces fever. The connection between TNF-α and cancer is mentioned as well.
ncbi.nlm.nih.gov/pubmed/23685857
10.1007/s00011-013-0633-0

From this research we know that
2.5
Ginger downregulates TNF-α
(BioMindmap Proof Quality is Acceptable.)
2.5
TNF-α increases Inflammation
(BioMindmap Proof Quality is Acceptable.)
2.5
TNF-α excess causes Cancer
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