6.2
ValidityScore
Valid or Invalid?
«The amount of totalMAPKs was not changed by bromelain treatment. However, we obtained down-regulated expression levels of both these MAP kinase
(Fig. 5) by bromelain via inhibition of their phosphorylation (p < 0.05)
but it did not much influence the phosphorylation of JNK1 in mouse
skin tumors in Gr. III when compared to DMBA treatment in Gr. II
(p < 0.05) (data not shown).»
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2016Systematic Review
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Noorjahan Banu Alitheen, Rajendran Ramesh, Samikannu Kanagesan, Subramaniam Sohila, Vidhya Rathnavelu -
«CONCLUSION: Bromelain has been recognized as a safe and successful type of therapeutic agent, and is being used by individuals worldwide for a number of ailments, such as bronchitis, sinusitis, arthritis and inflammation. Various findings from traditional and clinical reports indicate that bromelain may be an effective anticancer therapeutic agent. From the in vitro and in vivo data that is currently available, bromelain demonstrates immunomodulatory and anti-neoplastic effects, in addition to anti-inflammatory and anti-microbial effects. The above-mentioned experimental evidence clearly demonstrates that bromelain exhibits efficacious chemopreventive capabilities entailing antitumor-initiating and -promoting effects via inhibition of tumor development, which is underlined by induction of p53, shifts in the Bax/Bcl-2 ratio, induction of caspase, decreases in Cox-2 expression and inhibition of the NF-κB pathway by regulating MAPK and Akt/PKB signaling pathways. Future studies in this area may lead to promising results for bromelain-based cancer therapy, anti-microbial agents and health supplements.»
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2009Rodents
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Bhui K, et al. -
«Chemoprevention impels the pursuit for either single targeted or cocktail of multi-targeted agents. Bromelain, potential agent in this regard, is a pharmacologically active compound, present in stems and fruits of pineapple (Ananas cosmosus), endowed with anti-inflammatory, anti-invasive and anti-metastatic properties. Herein, we report the anti tumor-initiating effects of bromelain in 2-stage mouse skin tumorigenesis model. Pre-treatment of bromelain resulted in reduction in cumulative number of tumors (CNT) and average number of tumors per mouse. Preventive effect was also comprehended in terms of reduction in tumor volume up to a tune of approximately 65%. Components of the cell signaling pathways, connecting proteins involved in cell death were targeted. Bromelain treatment resulted in upregulation of p53 and Bax and subsequent activation of caspase 3 and caspase 9 with concomitant decrease in Bcl-2. A marked inhibition in cyclooxygenase-2 (Cox-2) expression and inactivation of nuclear factor-kappa B (NF-kappaB) was recorded, as phosphorylation and consequent degradation of I kappa B alpha was blocked by bromelain. Also, bromelain treatment curtailed extracellular signal regulated protein kinase (ERK1/2), p38 mitogen-activated protein kinase (MAPK) and Akt activity. The basis of anti tumor-initiating activity of bromelain was revealed by its time dependent reduction in DNA nick formation and increase in percentage prevention. Thus, modulation of inappropriate cell signaling cascades driven by bromelain is a coherent approach in achieving chemoprevention.»
- Organism: Mouse / Rat (Rodents)
- Comments: Swiss albino mice, female. 2 groups of 25 mice.
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#10-Dimethyl-1, 2-benzanthracene, 9, Animals, Anticarcinogenic Agents, Apoptosis, Bromelains, Cyclooxygenase 2 Inhibitors, Extracellular Signal-Regulated MAP Kinases, Female, Mice, Mitochondria, NF-kappa B, Proto-Oncogene Proteins c-akt, Proto-Oncogene Proteins c-bcl-2, Signal Transduction, Skin Neoplasms, Tetradecanoylphorbol Acetate, Tumor Suppressor Protein p53, p38 Mitogen-Activated Protein Kinases -
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on Apr 5, 2020