Chloroquine
inhibits
Coronavirus 2019
Chloroquine
inhibits
Coronavirus 2019
5.5
ValidityScore
Valid or Invalid?
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2020Systematic Review
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Cortegiani A, et al. -
«RESULTS: We included six articles (one narrative letter, one in-vitro study, one editorial, expert consensus paper, two national guideline documents) and 23 ongoing clinical trials in China. Chloroquine seems to be effective in limiting the replication of SARS-CoV-2 (virus causing COVID-19) in vitro.
CONCLUSIONS: There is rationale, pre-clinical evidence of effectiveness and evidence of safety from long-time clinical use for other indications to justify clinical research on chloroquine in patients with COVID-19. However, clinical use should either adhere to the Monitored Emergency Use of Unregistered Interventions (MEURI) framework or be ethically approved as a trial as stated by the World Health Organization. Safety data and data from high-quality clinical trials are urgently needed.» - Organism: In vitro
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2005
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Vincent MJ, et al. -
«RESULTS: We report, however, that chloroquine has strong antiviral effects on SARS-CoV infection of primate cell. These inhibitory effects are observed when the cell are treated with the drug either before or after exposure to the virus, suggesting both prophylactic and therapeutic advantage. In addition to the well-known functions of chloroquine such as elevations of endosomal pH, the drug appears to interfere with terminal glycosylation of the cellular receptor, angiotensin-converting enzyme 2. This may negatively influence the virus-receptor binding and abrogate the infection, with further ramifications by the elevation of vesicular pH, resulting in the inhibition of infection and spread of SARS CoV at clinically admissible concentration.
- Organism: In vitro
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#Ammonium Chloride, Animals, Antiviral Agents, Chlorocebus aethiops, Chloroquine, Coronavirus, Fluorescent Antibody Technique, Glycosylation, Indirect, Membrane Glycoproteins, Peptidyl-Dipeptidase A, SARS Virus, Severe Acute Respiratory Syndrome, Spike Glycoprotein, Vero Cells, Viral Envelope Proteinsmore... -
ranked
added it
3 years ago
on Mar 20, 2020