Higher doses of nano-TiO2 increased O2−, H2O2, and MDA levels, decreased the activities of the antioxidant enzymes APX, CAT, GSHPx, and SOD, decreased the levels of the non-enzymatic antioxidant ASA/DASA and GSH/GSSG, increased the levels of NO and activities of NOS, and decreased the levels of AchE and blood glucose (GLU) in the brain tissues (Figs. ​(Figs.99 and ​and10).10). These results suggest that nano-TiO2 may cause damage in the brain in mice after i.p. exposure.

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