Valid or Invalid?
Guangjun Yu, Ting Ge, Ting Zhang, Wenzhe Ho, Xiaolu Li, Yang Liao, Yizhong Wang, Yongmei Xiao, Yucai Zhang, Yun Cui
«RESULTS: A total of 23 trials involving 6269 children were eligible for inclusion in the systematic review. None of the trials showed a high risk of bias. The quality of the evidence of outcomes was moderate. The age range of subjects was from newborn to 18 years. The results of meta-analysis showed that probiotic consumption significantly decreased the number of subjects having at least 1 RTI episode (17 RCT, 4513 children, relative risk 0.89, 95% CI 0.82–0.96, P = 0.004). Children supplemented with probiotics had fewer numbers of days of RTI per person compared with children who had taken a placebo (6 RCT, 2067 children, MD -0.16, 95% CI -0.29 to 0.02, P = 0.03), and had fewer numbers of days absent from day care/school (8 RCT, 1499 children, MD -0.94, 95% CI -1.72 to -0.15, P = 0.02). However, there was no statistically significant difference of illness episode duration between probiotic intervention group and placebo group (9 RCT, 2817 children, MD -0.60, 95% CI -1.49 to 0.30, P = 0.19).
CONCLUSION: Based on the available data and taking into account the safety profile of RCT, probiotic consumption appears to be a feasible way to decrease the incidence of RTI in children.»
- Organism: Humans
- Notable Magnitude of Effect.
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