Vitamin B12
improves
Cognition
Vitamin B12
improves
Cognition
4.5
ValidityScore
Valid or Invalid?
«the Mini-Mental State Examination on >/=3 occasions during 10 y and related to serum concentration of vitamin B-12, holotranscobalamin (holoTC), tHcy, methylmalonic acid (MMA), and folate»
did they check b12 at all? not clear. They tracked Methylmalonate, a marker of B12
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2015Non Random CT
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Beulens JW., Biemans E1, Cuellar Renteria VG, Hart HE, Kooijman-Buiting AM, Rutten GE -
"AIMS:
To investigate the associations of vitamin B12 (cobalamin and holotranscobalamin) status with depression, cognition and neuropathy in patients with type 2 diabetes using metformin.
METHODS:
In an observational study, among 550 type 2 diabetes patients using metformin, cobalamin and holotranscobalamin (holoTCII) levels were measured at the annual diabetes checkup, and deficiencies were defined as <148 and <21 pmol/L, respectively. Depression and cognitive function were assessed with corresponding International Classification of Primary Care codes and questionnaires; neuropathy with medical record data and a questionnaire. Confounding variables were retrieved from medical records. Multivariable logistic and linear regressions were used with cobalamin status as independent variable; depression, cognition and neuropathy as dependent variables. - Organism: Humans
- Strong Magnitude of Effect.
- Comments: cobalamin-deficient patients had a 2.4 times higher chance of depression and a 1.79 point lower cognitive performance score
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2011Non Random CT
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Aggarwal NT, Decarli C, Evans DA, Li H, Morris MC., Tangney CC1, Wilson RS -
Concentration of all vitamin B12-related markers, but not serum vitamin B12 itself, were associated with global cognitive function and with total brain volume. Methylmalonate levels were associated with poorer episodic memory and perceptual speed, and cystathionine and 2-methylcitrate with poorer episodic and semantic memory. Homocysteine concentration were associated with decreased total brain volume.
serum markers of vitamin B12 status were related to summary measures of neuropsychological tests of 5 cognitive domains and brain MRI measures obtained on average 4.6 years later among 121 older adults. - Condition: older adults
- Organism: Humans
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"A doubling in holoTC concentrations (from 50 to 100 pmol/L) was associated with a 30% slower rate of cognitive decline (-0.137 to -0.083), whereas a doubling in tHcy (from 10 to 20 micromol/L) or MMA (from 0.25 to 0.50 micromol/L) was associated with >50% more rapid cognitive decline (-0.090 to -0.169) and (-0.104 to -0.169), respectively. After adjustment for all vitamin markers simultaneously, the associations of cognitive decline with holoTC and MMA remained significant."
- Organism: Humans
- Comments: elderly or just adults? unclear
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added it
1 year ago
on Feb 2, 2020