Pentoxifylline lowers TNF-α

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2018

RCT

The Phosphodiesterase Inhibitor Pentoxifylline as a Novel Adjunct to Antidepressants in Major Depressive Disorder Patients: A Proof-of-Concept, Ran...
El-Haggar SM, et al.
«RESULTS: After 8 and 12 weeks, the PTX group showed a statistically significantly greater improvement in HAM-D score compared to the control group (least squares mean difference [LSMD] -3.29, p = 0.000 and LSMD -3.49, p = 0.000, respectively). Moreover, the PTX group showed a statistically significantly greater reduction in the serum levels of TNF-α, IL-6, IL-10, and 8-OHdG along with a statistically significant increase in the levels of BDNF and serotonin in comparison with the control group after the treatment.

CONCLUSION: The findings of this study suggest that PTX could be a promising adjunct to antidepressant in the treatment of MDD patients.»
#Adult, Citalopram, Combination, Cytokines, Depressive Disorder, Double-Blind Method, Drug Therapy, Egypt, Female, Humans, Major, Male, Middle Aged, Pentoxifylline, Phosphodiesterase Inhibitors, Proof of Concept Study, Prospective Studies, Psychiatric Status Rating Scales, Treatment Outcome, Young Adultmore...
ncbi.nlm.nih.gov/pubmed/30205379
10.1159/000492619

From this research we know that
3.0
Pentoxifylline lowers IL-10
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Pentoxifylline lowers IL-6
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Pentoxifylline lowers TNF-α
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Pentoxifylline is Phosphodiesterase inhibitor
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2.8
Pentoxifylline improves Depression
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