Cholesterol that is too low may boost risk for hemorrhagic stroke
«Current guidelines recommend lowering cholesterol for heartdisease risk reduction. New findings indicate that if cholesterol dips too low, it may boost the risk of hemorrhagic stroke, according to researchers.»
«The researchers found that participants with LDLcholesterol levels below 70 mg/dL had a higher risk of hemorrhagic stroke.»
Low-density Lipoprotein Cholesterol and Risk of Intracerebral Hemorrhage: A Prospective Study, Systematic Review, and Meta-analysis (P18-029-19).
Ma C , et al.
«RESULTS: We identified 753 incident ICH cases during 9 years of follow-up. The ICH risk was similar among participants with LDLconcentration of 70-99 mg/dL and those with LDL-C concentration ≥100 mg/dL. In contrast, participants with LDL-C concentration less than 70 mg/dL had a significantly higher risk of developing ICH than those with LDL-C concentration of 70-99 mg/dL -adjusted HR 1.65 (95%CI, 1.32 to 2.05) for LDL-C concentration of 50-69 mg/dL and 2.69 (95%CI, 2.03 to 3.57) for LDL-C concentration of <50 mg/dL. In the meta-analysis of 11 prospective studies, the pooled HRs of hemorrhagic stroke for per 10 mg/dL decrement in LDL-C was 1.03 (95% CI, 1.01 to 1.06).
CONCLUSIONS: We observed a significant association between lowerLDL-C and higher risk of ICH when LDL-C concentration <70 mg/dL, and the risk decreased to a non-significance level and stabilized when LDL-C ≥70 mg/dL. These data can help determination of ideal LDL range in patients who are at increased risk of both atherosclerotic disease and hemorrhagic stroke and also guide planning of future lipid lowering studies.»
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