Gilbert's Syndrome may increase IL-1β

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Gilbert's Syndrome may decrease IL-1β
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2013

Haem catabolism: a novel modulator of inflammation in Gilbert's syndrome.
Wallner M, et al.
«RESULTS: Gilbert's syndrome subjects had significantly greater levels of unconjugated bilirubin (P < 0.05), carboxy haemoglobin (P < 0.05), iron (P < 0.05), IL-1β (P < 0.05), a significantly lower body mass index (P < 0.05) and IL-6 concentration (P < 0.05) vs. controls. Regression analysis revealed that unconjugated bilirubin mainly explained IL-1β results (16%), and body mass index+IL-6 predicted 26% of the variance in C-reactive protein concentration.

CONCLUSIONS: A positive relationship between unconjugated bilirubin and free plasma haem, iron and carboxy haemoglobin indicated a positive feedback loop of haem oxygenase induction possibly mediated by unconjugated bilirubin. Furthermore, reduced body mass index in Gilbert's syndrome individuals was linked to reduced inflammation status, which could be influenced by circulating haem oxygenase catabolites and contribute to reduced risk of noncommunicable diseases in this population.»
#80 and over, Adult, Aged, Aged, Bilirubin, C-Reactive Protein, Carboxyhemoglobin, Case-Control Studies, Enzyme-Linked Immunosorbent Assay, Female, Gilbert Disease, Heme, Heme Oxygenase (Decyclizing), Humans, Interleukin-1beta, Interleukin-6, Male, Middle Aged, Tumor Necrosis Factor-alpha, Young Adult
ncbi.nlm.nih.gov/pubmed/23865893
Read 10.1111/eci.12120

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