Baselineinflammation markers in serum such as CRP and SAA were only weakly inversely associated with UCB (r = −0.2, P = 0.02 and r = −0.19, P = 0.04, respectively), whereas IL-6 and IL-1β in monocytes showed a stronger inverse correlation (r = −0.301, P = 0.001 and r = −0.211, P = 0.023 respectively) which remained significant after age correction.
Significant dose dependent reduction in C-reactive protein (CRP; a chronic inflammatory biomarker) is consistently reported in individuals with elevated circulating bilirubin, being lowest in individuals with GS.
Significantly reduced plasma IL-6 has been reported in GS, indicating another possible mechanism of reduced platelet activity in vivo . Reducedconcentration of CRP, as seen in GS, might also reduce thrombus formation by inhibiting platelet adhesion to the endothelial surface 
«The protective effect of increased levels of indirect bilirubin on atherosclerotic heartdisease in patients of Gilbert's syndrome is well known. The aim of the study was to investigate the effects of increased levels of bilirubin on the mean platelet volume (MPV) and other hematological parameters. Thirty-two men and 36 women (a total of 68 Gilbert's syndromepatients) and a similar age group of 68 healthy individuals (32 men and 36 women) were included in the study. Hematologic tests, C-reactive protein (CRP) and biochemical values of the two groups were checked. MPV level of Gilbert's syndrome group was 7.8±1.0fl and CRP 0.2±0.27mg/dl. In the control group MPV was 8.6±1.0fl and CRP 0.3±0.38mg/dl. MPV of patients group (P<0.001) and CRP (P=0.037) were significantly lower than the control group. When dividing Gilbert's syndrome and control groups according to sex into subgroups the level of indirect bilirubin in men with Gilbert's syndrome (1.8±0.8mg/dl) was found to be higher than other groups. Healthymen had higher levels of MPV (8.8±0.9fl) whereas Gilbert's syndromemalepatients had lower levels (7.7±1.1fl), (P<0.001). The elevated levels of bilirubin and decreasing levels of MPV and CRP in Gilbert's syndromepatients may have an effect on the slowing down of the atherosclerotic process.»
«RESULTS: Age, gender and body mass index (BMI) distributions were similar between the two groups. sd-LDL-C, ox-LDL and hs-CRP levels were lower in GS than the healthycontrols (p<0.001, p<0.001 and p=0.001, respectively). Unconjugated bilirubin was negatively correlated with sd-LDL-C, ox-LDL and hs-CRP (r=-0.594, p<0.001; r=-0.249, p=0.016 and r=-0.373, p<0.001 respectively). In addition, sd-LDL-C was positively correlated with ox-LDL (r=0.307, p=0.003).
CONCLUSIONS: The findings of this preliminary study suggest that reduced sd-LDL-C, ox-LDL and hs-CRP levels may have a role in preventing atherosclerosis in subjects with GS.»
«RESULTS: sCD40L and hs-CRP levels were significantly lower in GS compared to the controls (0.33+/-0.27 vs 0.71+/-0.37 ng/mL, p<0.001 and 0.51+/-0.45 vs 1.16+/-1.31 mg/L, p=0.046, respectively). Both sCD40L and hs-CRP were negatively correlated with total bilirubin (r=-0.5, p<0.001 and r=-0.34, p=0.002, respectively). sP-selectin levels were lower in GS when compared to the controls but the difference did not reach statistical significance (p=0.052). No correlation was found between the plasma levels of sCD40L, sP-selectin and hs-CRP.