Gilbert's Syndrome decreases Interleukin 6

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Gilbert's Syndrome decreases IL-6

5.1 ValidityScore

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Proofs

2016

Longer telomeres in chronic, moderate, unconjugated hyperbilirubinaemia: insights from a human study on Gilbert’s Syndrome
Anela Tosevska, Carina Kern, Christine Moelzer, Daniel Doberer, Karl-Heinz Wagner, Marlies Wallner, Milan Janosec, Rodrig Marculescu, Ursula Schwarz, Wolfram Weckwerth
Baseline inflammation markers in serum such as CRP and SAA were only weakly inversely associated with UCB (r = −0.2, P = 0.02 and r = −0.19, P = 0.04, respectively), whereas IL-6 and IL-1β in monocytes showed a stronger inverse correlation (r = −0.301, P = 0.001 and r = −0.211, P = 0.023 respectively) which remained significant after age correction.

UCB might affect the immune response by downregulating intracellular production of cytokines, as evident from the lower levels of IL6 and IL-1β in monocytes from GS individuals, in particularly males (sup. Table S1).
ncbi.nlm.nih.gov/pmc/articles/PMC4772088
Read 10.1038/srep22300

From this research we know that
6.3
Gilbert's Syndrome decreases CRP
1.5
Gilbert's Syndrome may lower Serum Amyloid A
(BioMindmap Proof Quality is Low.)
5.1
Gilbert's Syndrome decreases IL-6
1.5
Ageing may improve Gilbert's Syndrome
(BioMindmap Proof Quality is Low.)
0.6
Gilbert's Syndrome may increase Telomere length
(BioMindmap Proof Quality is Very Light.)
0.6
Gilbert's Syndrome may decrease IL-1β
(BioMindmap Proof Quality is Very Light.)

2015

Bilirubin, platelet activation and heart disease: a missing link to cardiovascular protection in Gilbert's syndrome?
Kundur AR, et al.
Significantly reduced plasma IL-6 has been reported in GS, indicating another possible mechanism of reduced platelet activity in vivo [35]. Reduced concentration of CRP, as seen in GS, might also reduce thrombus formation by inhibiting platelet adhesion to the endothelial surface [35]
#Animals, Antioxidants, Bilirubin, Body Mass Index, Cardiovascular Diseases, Collagen, Gilbert Disease, Humans, Inflammation, Lipid Metabolism, Myocardial Infarction, Oxidative Stress, Oxygen, Reactive Oxygen Species, Thrombosis
ncbi.nlm.nih.gov/pubmed/25576848
Read 10.1016/j.atherosclerosis.2014.12.042

From this research we know that
3.3
Gilbert's Syndrome may decrease Thrombosis
(BioMindmap Proof Quality is Acceptable.)
6.3
Gilbert's Syndrome decreases CRP
4.4
Gilbert's Syndrome decreases Platelets
1.1
Gilbert's Syndrome may prevent Ischemic heart disease
(BioMindmap Proof Quality is Low.)
1.6
Gilbert's Syndrome decreases Free radicals
(BioMindmap Proof Quality is Low.)
5.1
Gilbert's Syndrome decreases IL-6
3.3
Gilbert's Syndrome may increase Hemoglobin
(BioMindmap Proof Quality is Acceptable.)
3.1
Gilbert's Syndrome may increase Hematocrit
(BioMindmap Proof Quality is Acceptable.)
0.8
Gilbert's Syndrome may prevent Thrombosis
(BioMindmap Proof Quality is Very Light.)
0.8
Gilbert's Syndrome may increase MCH
(BioMindmap Proof Quality is Very Light.)
0.8
Gilbert's Syndrome may increase MCHC
(BioMindmap Proof Quality is Very Light.)
0.8
Gilbert's Syndrome may prevent Atherogenesis
(BioMindmap Proof Quality is Very Light.)
0.6
Gilbert's Syndrome may protect Diabetes Type 2
(BioMindmap Proof Quality is Very Light.)
0.8
Gilbert's Syndrome may prevent Metabolic disorder
(BioMindmap Proof Quality is Very Light.)
0.8
Gilbert's Syndrome may increase Insulin sensitivity
(BioMindmap Proof Quality is Very Light.)
0.6
Gilbert's Syndrome may increase Insulin signaling
(BioMindmap Proof Quality is Very Light.)
0.8
Gilbert's Syndrome may increase Glucose tolerance
(BioMindmap Proof Quality is Very Light.)
0.6
Gilbert's Syndrome may prevent Familial Hypercholesterolemia
(BioMindmap Proof Quality is Very Light.)
0.8
Gilbert's Syndrome may prevent Myocardial Infarction
(BioMindmap Proof Quality is Very Light.)
0.8
Gilbert's Syndrome may prevent Peripheral Arterial Disease
(BioMindmap Proof Quality is Very Light.)
1.8
Gilbert's Syndrome decreases P-selectin
(BioMindmap Proof Quality is Low.)
1.6
Gilbert's Syndrome decreases CD40L
(BioMindmap Proof Quality is Low.)
1.8
UCB decreases Free radicals
(BioMindmap Proof Quality is Low.)
1.9
Gilbert's Syndrome increases Antioxidant capacity
(BioMindmap Proof Quality is Low.)
1.8
Gilbert's Syndrome decreases Thiol
(BioMindmap Proof Quality is Low.)
1.8
Gilbert's Syndrome decreases Glutathione
(BioMindmap Proof Quality is Low.)

2013

Haem catabolism: a novel modulator of inflammation in Gilbert's syndrome.
Wallner M, et al.
«RESULTS: Gilbert's syndrome subjects had significantly greater levels of unconjugated bilirubin (P < 0.05), carboxy haemoglobin (P < 0.05), iron (P < 0.05), IL-1β (P < 0.05), a significantly lower body mass index (P < 0.05) and IL-6 concentration (P < 0.05) vs. controls. Regression analysis revealed that unconjugated bilirubin mainly explained IL-1β results (16%), and body mass index+IL-6 predicted 26% of the variance in C-reactive protein concentration.

CONCLUSIONS: A positive relationship between unconjugated bilirubin and free plasma haem, iron and carboxy haemoglobin indicated a positive feedback loop of haem oxygenase induction possibly mediated by unconjugated bilirubin. Furthermore, reduced body mass index in Gilbert's syndrome individuals was linked to reduced inflammation status, which could be influenced by circulating haem oxygenase catabolites and contribute to reduced risk of noncommunicable diseases in this population.»
#80 and over, Adult, Aged, Aged, Bilirubin, C-Reactive Protein, Carboxyhemoglobin, Case-Control Studies, Enzyme-Linked Immunosorbent Assay, Female, Gilbert Disease, Heme, Heme Oxygenase (Decyclizing), Humans, Interleukin-1beta, Interleukin-6, Male, Middle Aged, Tumor Necrosis Factor-alpha, Young Adult
ncbi.nlm.nih.gov/pubmed/23865893
Read 10.1111/eci.12120

From this research we know that
4.1
Gilbert's Syndrome may decrease BMI
5.1
Gilbert's Syndrome decreases IL-6
0.6
Gilbert's Syndrome may increase IL-1β
(BioMindmap Proof Quality is Very Light.)
0.6
Gilbert's Syndrome may increase Free plasma haem
(BioMindmap Proof Quality is Very Light.)
0.6
Gilbert's Syndrome may increase Carboxy haemoglobin
(BioMindmap Proof Quality is Very Light.)
0.8
Gilbert's Syndrome may increase Iron
(BioMindmap Proof Quality is Very Light.)

2013

Protection from age-related increase in lipid biomarkers and inflammation contributes to cardiovascular protection in Gilbert's syndrome.
Wallner M, et al.
Pro-inflammatory markers
SAA is a pro-inflammatory adipokine in humans linked to
obesity and is a predictor of CVD [24,41]
Comments: Pro-inflammatory markers
SAA is a pro-inflammatory adipokine in humans linked to
obesity and is a predictor of CVD [24,41]
#Adult, Aging, Animal, Animals, Bilirubin, Biomarkers, Cardiovascular Diseases, Case-Control Studies, Disease Models, Female, Gilbert Disease, Gunn, Humans, Inflammation, Lipoproteins, Male, Middle Aged, Rats, Rats, Young Adult
ncbi.nlm.nih.gov/pubmed/23566065
Read 10.1042/CS20120661

From this research we know that
2.5
Gilbert's Syndrome decreases Triglycerides
(BioMindmap Proof Quality is Acceptable.)
4.1
Gilbert's Syndrome may decrease BMI
1.5
Gilbert's Syndrome may prevent CVD
(BioMindmap Proof Quality is Low.)
1.5
Gilbert's Syndrome may lower Serum Amyloid A
(BioMindmap Proof Quality is Low.)
1.8
Gilbert's Syndrome reduces Apolipoprotein B
(BioMindmap Proof Quality is Low.)
2.5
Gilbert's Syndrome decreases Cholesterol
(BioMindmap Proof Quality is Acceptable.)
5.1
Gilbert's Syndrome decreases IL-6
7.0
Gilbert's Syndrome decreases LDL
+1
1.5
Gilbert's Syndrome may increase Bilirubin
(BioMindmap Proof Quality is Low.)
1.4
Gilbert's Syndrome reduces Apo-A1
(BioMindmap Proof Quality is Low.)
1.8
Gilbert's Syndrome reduces SAA
(BioMindmap Proof Quality is Low.)
1.5
Serum Amyloid A is marker of CVD
(BioMindmap Proof Quality is Low.)
1.5
Apo-B/Apo-A1 ratio is marker of CVD
(BioMindmap Proof Quality is Low.)
0.6
Gilbert's Syndrome may reduce IDL-3
(BioMindmap Proof Quality is Very Light.)
-2.4
Perhaps, Gilbert's Syndrome may reduce LDL-1
(BioMindmap Proof Quality is Negative.) (BioMindmap had flagged this statement.)
1.8
IL-6 induces CRP
(BioMindmap Proof Quality is Low.)
0.8
CRP may increase CVD
(BioMindmap Proof Quality is Very Light.)
0.6
CRP may increase Diabetes Type 2
(BioMindmap Proof Quality is Very Light.)
0.6
Gilbert's Syndrome may decrease IDL
(BioMindmap Proof Quality is Very Light.)
0.8
Gilbert's Syndrome may decrease VLDL
(BioMindmap Proof Quality is Very Light.)
0.6
Gilbert's Syndrome may decrease Apo-B/Apo-A1 ratio
(BioMindmap Proof Quality is Very Light.)

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