Gilbert's Syndrome
decreases
IL-6
Gilbert's Syndrome
decreases
IL-6
5.1
ValidityScore
Valid or Invalid?
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2016
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Anela Tosevska, Carina Kern, Christine Moelzer, Daniel Doberer, Karl-Heinz Wagner, Marlies Wallner, Milan Janosec, Rodrig Marculescu, Ursula Schwarz, Wolfram Weckwerth
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Baseline inflammation markers in serum such as CRP and SAA were only weakly inversely associated with UCB (r = −0.2, P = 0.02 and r = −0.19, P = 0.04, respectively), whereas IL-6 and IL-1β in monocytes showed a stronger inverse correlation (r = −0.301, P = 0.001 and r = −0.211, P = 0.023 respectively) which remained significant after age correction.
UCB might affect the immune response by downregulating intracellular production of cytokines, as evident from the lower levels of IL6 and IL-1β in monocytes from GS individuals, in particularly males (sup. Table S1). -
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2015
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Kundur AR, et al.
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Significantly reduced plasma IL-6 has been reported in GS, indicating another possible mechanism of reduced platelet activity in vivo [35]. Reduced concentration of CRP, as seen in GS, might also reduce thrombus formation by inhibiting platelet adhesion to the endothelial surface [35]
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2013
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Wallner M, et al.
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«RESULTS: Gilbert's syndrome subjects had significantly greater levels of unconjugated bilirubin (P < 0.05), carboxy haemoglobin (P < 0.05), iron (P < 0.05), IL-1β (P < 0.05), a significantly lower body mass index (P < 0.05) and IL-6 concentration (P < 0.05) vs. controls. Regression analysis revealed that unconjugated bilirubin mainly explained IL-1β results (16%), and body mass index+IL-6 predicted 26% of the variance in C-reactive protein concentration.
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#80 and over, Adult, Aged, Aged, Bilirubin, C-Reactive Protein, Carboxyhemoglobin, Case-Control Studies, Enzyme-Linked Immunosorbent Assay, Female, Gilbert Disease, Heme, Heme Oxygenase (Decyclizing), Humans, Interleukin-1beta, Interleukin-6, Male, Middle Aged, Tumor Necrosis Factor-alpha, Young Adult
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2013
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Wallner M, et al.
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Comments:
Pro-inflammatory markers
SAA is a pro-inflammatory adipokine in humans linked to
obesity and is a predictor of CVD [24,41] -
- From this research we know that
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-2.4Perhaps, Gilbert's Syndrome may reduce LDL-1(BioMindmap Proof Quality is Negative.) (BioMindmap had flagged this statement.)
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1 year ago
on Apr 27, 2019
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