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Longer telomeres in chronic, moderate, unconjugated hyperbilirubinaemia: insights from a human study on Gilbert’s Syndrome
Anela Tosevska, Christine Moelzer, Marlies Wallner, Milan Janosec, Ursula Schwarz, Carina Kern, Rodrig Marculescu, Daniel Doberer, Wolfram Weckwerth, Karl-Heinz Wagner
Mean telomere length (TL) was greater in GS subjects (6.25 kb ± 1.97, mean ± s.d.) compared to controls (5.47 kb ± 2.09, P = 0.033; paired t-test), which became more pronounced after correcting for age and gender (P = 0.002 for the whole model, P = 0.02 for GS phenotype).
Baseline inflammation markers in serum such as CRP and SAA were only weakly inversely associated with UCB (r = −0.2, P = 0.02 and r = −0.19, P = 0.04, respectively), whereas IL-6 and IL-1β in monocytes showed a stronger inverse correlation (r = −0.301, P = 0.001 and r = −0.211, P = 0.023 respectively) which remained significant after age correction.
UCB might affect the immune response by downregulating intracellular production of cytokines, as evident from the lower levels of IL6 and IL-1β in monocytes from GS individuals, in particularly males (sup. Table S1).
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