Mean telomere length
(TL) was greater in GS subjects (6.25 kb ± 1.97, mean
± s.d.) compared to controls
(5.47 kb ± 2.09, P = 0.033; paired t-test), which became more pronounced after correcting for age
and gender (P = 0.002 for the whole model, P = 0.02 for GS phenotype).
markers in serum such as CRP
were only weakly inversely associated
(r = −0.2, P = 0.02 and r = −0.19, P = 0.04, respectively), whereas IL-6
and IL-1β in monocytes showed a stronger inverse correlation
(r = −0.301, P = 0.001 and r = −0.211, P = 0.023 respectively) which remained significant
might affect the immune response
by downregulating intracellular production of cytokines, as evident
from the lower
levels of IL6
and IL-1β in monocytes from GS individuals, in particularly males
(sup. Table S1).