Gilbert's Syndrome
may increase
Hematocrit
(BioMindmap Proof Quality is Acceptable.)
Gilbert's Syndrome
may increase
Hematocrit
(BioMindmap Proof Quality is Acceptable.)
3.1
ValidityScore
Valid or Invalid?
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2018
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Wagner KH, et al. -
Furthermore, in adults, increased red cell mass, and therefore hemoglobin turnover, is also associated with increased bilirubin concentration. Some evidence of this has been observed in individuals with GS [43]; in this study, more than 800 individuals (males and females) with GS demonstrated increased hemoglobin,
RBC count and hematocrit (typically, increases of 2–3%), compared to age- and gender-matched controls.
Importantly, no difference in red cell volume was noted and all patients were otherwise healthy. Another crosssectional study demonstrated increased total hemoglobin and RBC counts in GS vs. randomly-selected controls [44], which was supported by a smaller case-control study [45]. -
Comments:
Furthermore, in adults, increased red cell mass, and therefore hemoglobin turnover, is also associated with increased bilirubin concentration. Some evidence of this has been observed in individuals with GS [43]; in this study, more than 800 individuals (males and females) with GS demonstrated increased hemoglobin,
RBC count and hematocrit (typically, increases of 2–3%), compared to age- and gender-matched controls.
Importantly, no difference in red cell volume was noted and all patients were otherwise healthy. Another crosssectional study demonstrated increased total hemoglobin and RBC counts in GS vs. randomly-selected controls [44], which was supported by a smaller case-control study [45]. -
- From this research we know that
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-3.1Perhaps, Obesity may improve Gilbert's Syndrome(BioMindmap Proof Quality is Negative.) (BioMindmap had flagged this statement.)
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2015
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Kundur AR, et al. -
a positive correlation between serum bilirubin and hemoglobin concentration, hematocrit, mean cell hemoglobin (MCH) and mean cell hemoglobin concentration (MCHC), red cell count were reported in GS
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2008
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Buyukasik Y, et al. -
«RESULTS: In 48,516 otherwise normal laboratory test results, we have found that 491 male subjects and 323 female subjects with unconjugated hyperbilirubinemia had higher hemoglobin, hematocrit, and red blood cell values compared with age- and gender-matched control subjects (P < 0.001 for all comparisons). Twenty-six males who had been followed for Gilbert's syndrome also showed higher hemoglobin, hematocrit and red cell count values in comparison to all control groups. Mean red cell volume value did not differ between the hyperbilirubinemic persons and control groups.
CONCLUSIONS: Relatively increased red cell mass probably plays a role in the pathogenesis of Gilbert's syndrome.» -
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added it
1 year ago
on Apr 14, 2019