Ageing may improve Gilbert's Syndrome

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Ageing may improve Gilbert's Syndrome
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Proofs

2016

Longer telomeres in chronic, moderate, unconjugated hyperbilirubinaemia: insights from a human study on Gilbert’s Syndrome
Anela Tosevska, Carina Kern, Christine Moelzer, Daniel Doberer, Karl-Heinz Wagner, Marlies Wallner, Milan Janosec, Rodrig Marculescu, Ursula Schwarz, Wolfram Weckwerth
UCB levels had a tendency to decrease with age in the control group (r = −0.274, P = 0.034,
ncbi.nlm.nih.gov/pmc/articles/PMC4772088
Read 10.1038/srep22300

From this research we know that
6.3
Gilbert's Syndrome decreases CRP
1.5
Gilbert's Syndrome may lower Serum Amyloid A
(BioMindmap Proof Quality is Low.)
5.1
Gilbert's Syndrome decreases IL-6
1.5
Ageing may improve Gilbert's Syndrome
(BioMindmap Proof Quality is Low.)
0.6
Gilbert's Syndrome may increase Telomere length
(BioMindmap Proof Quality is Very Light.)
0.6
Gilbert's Syndrome may decrease IL-1β
(BioMindmap Proof Quality is Very Light.)

2018

Diagnostic criteria and contributors to Gilbert's syndrome.
Wagner KH, et al.
Circulating bilirubin concentration are determined by the rate of heme catabolism, absorption of bilirubin from the gut, hepatic excretion, and trans-epithelial transport from blood to the gut. Therefore, factors affecting these processes can potentially lead to
increased bilirubin concentration - Figure 4. Factors affecting circulating unconjugated bilirubin
concentration.
Comments: Circulating bilirubin concentration are determined by the rate of heme catabolism, absorption of bilirubin from the gut, hepatic excretion, and trans-epithelial transport from blood to the gut. Therefore, factors affecting these processes can potentially lead to
increased bilirubin concentration - Figure 4. Factors affecting circulating unconjugated bilirubin
concentration.
#Bilirubin, Gilbert Disease, Glucuronosyltransferase, Humans, Hyperbilirubinemia
ncbi.nlm.nih.gov/pubmed/29390925
Read 10.1080/10408363.2018.1428526

From this research we know that
1.5
Ageing may improve Gilbert's Syndrome
(BioMindmap Proof Quality is Low.)
3.3
Gilbert's Syndrome may increase Hemoglobin
(BioMindmap Proof Quality is Acceptable.)
3.1
Gilbert's Syndrome may increase Hematocrit
(BioMindmap Proof Quality is Acceptable.)
0.6
Thyroid hormone may inhibit UGT1A1
(BioMindmap Proof Quality is Very Light.)
0.5
RBC turnover may worsen Gilbert's Syndrome
(BioMindmap Proof Quality is Very Light.)
0.8
Gilbert's Syndrome may cause Hemolysis
(BioMindmap Proof Quality is Very Light.)
0.6
Gilbert's Syndrome may increase RBC count
(BioMindmap Proof Quality is Very Light.)
1.4
Gilbert's Syndrome does not affect RBC volume
(BioMindmap Proof Quality is Low.)
0.6
Alcohol may worsen Gilbert's Syndrome
(BioMindmap Proof Quality is Very Light.)
0.6
Fatty Liver may worsen Gilbert's Syndrome
(BioMindmap Proof Quality is Very Light.)
0.3
Spherocytosis may worsen Gilbert's Syndrome
(BioMindmap Proof Quality is Very Light.)
0.3
Transfusion may worsen Gilbert's Syndrome
(BioMindmap Proof Quality is Very Light.)
0.3
Iron defficiency may inhibit Gilbert's Syndrome
(BioMindmap Proof Quality is Very Light.)
0.3
Iron defficiency may improve Gilbert's Syndrome
(BioMindmap Proof Quality is Very Light.)
-3.1
Perhaps, Obesity may improve Gilbert's Syndrome
(BioMindmap Proof Quality is Negative.) (BioMindmap had flagged this statement.)
0.3
Illness may worsen Gilbert's Syndrome
(BioMindmap Proof Quality is Very Light.)
0.3
HyperBilirubinemia may cause Neurotoxicity
(BioMindmap Proof Quality is Very Light.)

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