Gilbert's Syndrome may prevent Cardiovascular Diseases

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Gilbert's Syndrome may prevent CVD
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1.5 ValidityScore

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1.6
Gilbert's Syndrome decreases CVD
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Proofs

2017

Mild hyperbilirubinaemia as an endogenous mitigator of overweight and obesity: Implications for improved metabolic health.
Seyed Khoei N, et al.
Phenotypically, the Framingham heart study showed that higher
serum bilirubin was associated with lower risk of CVD [9] and a
different study (meta-analysis, ~15,000 men), demonstrated that
each 1 mmol/l increase in serum bilirubin was associated with a
6.5% CVD risk reduction
#Anthropometric data, Bilirubin, Cardiovascular disease (CVD) risk factors, Lipid profile, Overweight/obesity, Unconjugated bilirubin (UCB)
ncbi.nlm.nih.gov/pubmed/29279144
Read 10.1016/j.atherosclerosis.2017.12.021

From this research we know that
4.1
Gilbert's Syndrome may decrease BMI
1.2
Gilbert's Syndrome may inhibit Weight gain
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1.5
Gilbert's Syndrome may prevent CVD
(BioMindmap Proof Quality is Low.)
7.0
Gilbert's Syndrome decreases LDL
+1
0.3
Fat Mass may improve Gilbert's Syndrome
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0.4
Gilbert's Syndrome may decrease Waist-hip-ratio
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0.8
Gilbert's Syndrome may prevent Obesity
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2013

Protection from age-related increase in lipid biomarkers and inflammation contributes to cardiovascular protection in Gilbert's syndrome.
Wallner M, et al.
The results of the present study provide three lines of evidence to
suggest protection from age-related dyslipidaemia/inflammation
in GS. First, BMI, total cholesterol, TAG, LDL-C, LDL subfractions, Apo-B, the Apo-B/Apo-A1 ratio, SAA and IL-6 were significantly lower in age GS compared with matched controls.

Together, these data provide the translational evidence that bilirubin or its metabolism modulates lipid metabolism in humans, which could contribute to reduced CVD risk in GS.
Comments: The results of the present study provide three lines of evidence to
suggest protection from age-related dyslipidaemia/inflammation
in GS. First, BMI, total cholesterol, TAG, LDL-C, LDL subfractions, Apo-B, the Apo-B/Apo-A1 ratio, SAA and IL-6 were significantly lower in age GS compared with matched controls.

Together, these data provide the translational evidence that bilirubin or its metabolism modulates lipid metabolism in humans, which could contribute to reduced CVD risk in GS.
#Adult, Aging, Animal, Animals, Bilirubin, Biomarkers, Cardiovascular Diseases, Case-Control Studies, Disease Models, Female, Gilbert Disease, Gunn, Humans, Inflammation, Lipoproteins, Male, Middle Aged, Rats, Rats, Young Adult
ncbi.nlm.nih.gov/pubmed/23566065
Read 10.1042/CS20120661

From this research we know that
2.5
Gilbert's Syndrome decreases Triglycerides
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4.1
Gilbert's Syndrome may decrease BMI
1.5
Gilbert's Syndrome may prevent CVD
(BioMindmap Proof Quality is Low.)
1.5
Gilbert's Syndrome may lower Serum Amyloid A
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1.8
Gilbert's Syndrome reduces Apolipoprotein B
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2.5
Gilbert's Syndrome decreases Cholesterol
(BioMindmap Proof Quality is Acceptable.)
5.1
Gilbert's Syndrome decreases IL-6
7.0
Gilbert's Syndrome decreases LDL
+1
1.5
Gilbert's Syndrome may increase Bilirubin
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1.4
Gilbert's Syndrome reduces Apo-A1
(BioMindmap Proof Quality is Low.)
1.8
Gilbert's Syndrome reduces SAA
(BioMindmap Proof Quality is Low.)
1.5
Serum Amyloid A is marker of CVD
(BioMindmap Proof Quality is Low.)
1.5
Apo-B/Apo-A1 ratio is marker of CVD
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0.6
Gilbert's Syndrome may reduce IDL-3
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-2.4
Perhaps, Gilbert's Syndrome may reduce LDL-1
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1.8
IL-6 induces CRP
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0.8
CRP may increase CVD
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0.6
CRP may increase Diabetes Type 2
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0.6
Gilbert's Syndrome may decrease IDL
(BioMindmap Proof Quality is Very Light.)
0.8
Gilbert's Syndrome may decrease VLDL
(BioMindmap Proof Quality is Very Light.)
0.6
Gilbert's Syndrome may decrease Apo-B/Apo-A1 ratio
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Gilbert's Syndrome may prevent CVD
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