Gilbert's Syndrome may prevent Cardiovascular Diseases

Edit Gilbert's Syndrome may prevent CVD

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1.3 Gilbert's Syndrome decreases CVD

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2017

Mild hyperbilirubinaemia as an endogenous mitigator of overweight and obesity: Implications for improved metabolic health.
Seyed Khoei N, et al.
Phenotypically, the Framingham heart study showed that higher serum bilirubin was associated with lower risk of CVD [9] and a different study (meta-analysis, ~15,000 men), demonstrated that each 1 mmol/l increase in serum bilirubin was associated with a
6.5% CVD risk reduction
#Anthropometric data, Bilirubin, Cardiovascular disease (CVD) risk factors, Lipid profile, Overweight/obesity, Unconjugated bilirubin (UCB)
ncbi.nlm.nih.gov/pubmed/29279144
10.1016/j.atherosclerosis.2017.12.021

2013

Protection from age-related increase in lipid biomarkers and inflammation contributes to cardiovascular protection in Gilbert's syndrome.
Wallner M, et al.
The results of the present study provide three lines of evidence to suggest protection from age-related dyslipidaemia/inflammation in GS. First, BMI, total cholesterol, TAG, LDL-C, LDL subfractions, Apo-B, the Apo-B/Apo-A1 ratio, SAA and IL-6 were significantly lower in age GS compared with matched controls.

Together, these data provide the translational evidence that bilirubin or its metabolism modulates lipid metabolism in humans, which could contribute to reduced CVD risk in GS.
Comments: The results of the present study provide three lines of evidence to suggest protection from age-related dyslipidaemia/inflammation in GS. First, BMI, total cholesterol, TAG, LDL-C, LDL subfractions, Apo-B, the Apo-B/Apo-A1 ratio, SAA and IL-6 were significantly lower in age GS compared with matched controls.

Together, these data provide the translational evidence that bilirubin or its metabolism modulates lipid metabolism in humans, which could contribute to reduced CVD risk in GS.
#Adult, Aging, Animal, Animals, Bilirubin, Biomarkers, Cardiovascular Diseases, Case-Control Studies, Disease Models, Female, Gilbert Disease, Gunn, Humans, Inflammation, Lipoproteins, Male, Middle Aged, Rats, Rats, Young Adult
ncbi.nlm.nih.gov/pubmed/23566065
10.1042/CS20120661

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