editEdit Gilbert's syndrome may prevent CVD
Sources
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2017
Mild hyperbilirubinaemia as an endogenous mitigator of overweight and obesity: Implications for improved metabolic health.
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Seyed Khoei N, et al. -
Phenotypically, the Framingham heart study showed that higher serum bilirubin was associated with lower risk of CVD [9] and a different study (meta-analysis, ~15,000 men), demonstrated that each 1 mmol/l increase in serum bilirubin was associated with a
6.5% CVD risk reduction -
Anthropometric data, Bilirubin, Cardiovascular disease (CVD) risk factors, Lipid profile, Overweight/obesity, Unconjugated bilirubin (UCB) -
https://www.ncbi.nlm.nih.gov/pubmed/29279144 10.1016/j.atherosclerosis.2017.12.021
- From this research we know that
- Gilbert's syndrome may prevent CVD
- Gilbert's syndrome may decrease BMI
- Gilbert's syndrome decreases LDL
- Fat Mass may improve Gilbert's syndrome
- Gilbert's syndrome may decrease Waist-hip-ratio
- Gilbert's syndrome may prevent Obesity
- Gilbert's syndrome may inhibit Weight gain
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2013
Protection from age-related increase in lipid biomarkers and inflammation contributes to cardiovascular protection in Gilbert's syndrome.
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Wallner M, et al. -
The results of the present study provide three lines of evidence to suggest protection from age-related dyslipidaemia/inflammation in GS. First, BMI, total cholesterol, TAG, LDL-C, LDL subfractions, Apo-B, the Apo-B/Apo-A1 ratio, SAA and IL-6 were significantly lower in aged GS compared with matched controls.
Together, these data provide the translational evidence that bilirubin or its metabolism modulates lipid metabolism in humans, which could contribute to reduced CVD risk in GS. -
Comments:
The results of the present study provide three lines of evidence to suggest protection from age-related dyslipidaemia/inflammation in GS. First, BMI, total cholesterol, TAG, LDL-C, LDL subfractions, Apo-B, the Apo-B/Apo-A1 ratio, SAA and IL-6 were significantly lower in aged GS compared with matched controls.
Together, these data provide the translational evidence that bilirubin or its metabolism modulates lipid metabolism in humans, which could contribute to reduced CVD risk in GS. -
Adult, Aging, Animal, Animals, Bilirubin, Biomarkers, Cardiovascular Diseases, Case-Control Studies, Disease Models, Female, Gilbert Disease, Gunn, Humans, Inflammation, Lipoproteins, Male, Middle Aged, Rats, Rats, Young Adult -
https://www.ncbi.nlm.nih.gov/pubmed/23566065 10.1042/CS20120661
- From this research we know that
- Gilbert's syndrome may prevent CVD
- Gilbert's syndrome may lower Serum Amyloid A
- Gilbert's syndrome decreases TAG
- Gilbert's syndrome may decrease BMI
- Gilbert's syndrome reduces Apo-B
- Gilbert's syndrome decreases Cholesterol
- Gilbert's syndrome decreases IL-6
- Gilbert's syndrome decreases LDL
- Gilbert's syndrome may increase Bilirubin
- Gilbert's syndrome reduces Apo-A1
- Gilbert's syndrome reduces SAA
- Serum Amyloid A is marker of CVD
- Apo-B/Apo-A1 ratio is marker of CVD
- Gilbert's syndrome may reduce IDL-3
- Gilbert's syndrome may reduce LDL-1
- IL-6 induces CRP
- CRP may increase CVD
- CRP may increase Diabetes Type 2
- Gilbert's syndrome may decrease IDL
- Gilbert's syndrome may decrease VLDL
- Gilbert's syndrome may decrease Apo-B/Apo-A1 ratio