Gilbert's Syndrome may decrease Body Mass Index

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Gilbert's Syndrome may decrease BMI

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2017

Cohort

Mild hyperbilirubinaemia as an endogenous mitigator of overweight and obesity: Implications for improved metabolic health.
Seyed Khoei N, et al.
The results presented highlight the potential of bilirubin
metabolism in contributing to the prevention of overweight/
obesity, particularly during aging. In our study, 25% of GS subjects,
compared to 46% in the HCG were overweight/obese. In the older
subgroup (mean age: 52 yrs), these figures increased to 35% and
69%, respectively. Data analysis revealed significantly lower
abdominal obesity in GS compared to the HCG, indicated by a
smaller HC and WC, remarkably in the older group.

The GS group had higher serum UCB (30.7 ± 11.4 vs. 8.7 ± 3.6,
p < .001), lower BMI (8%, p < 0.001) and HC (4%, p <0 .01) compared
to the HCG. 25% of GS and 46% of the HCG were overweight/obese
(p <0 .01). Further biologically relevant yet non-significant differences in WC, abdominal circumference (AC), WHR and the FM were
found between the groups

«RESULTS: BMI, hip circumference (HC), and lipid profile were significantly lower in GS. UCB was inversely correlated with BMI (p <0 .001), HC as well as with fat mass (FM) and lipid variables (p < 0.05). Moreover, DM2 patients had significantly lower UCB compared to GS and healthy controls. Older GS subjects (≥35 years) had significantly reduced anthropometric data and improved lipid profile.

CONCLUSIONS: Our results propose that the health promoting potential of mild hyperbilirubinaemia may extend to protection from age-related weight gain and dyslipidaemia.»
Organism: Humans
#Anthropometric data, Bilirubin, Cardiovascular disease (CVD) risk factors, Lipid profile, Overweight/obesity, Unconjugated bilirubin (UCB)
ncbi.nlm.nih.gov/pubmed/29279144
Read 10.1016/j.atherosclerosis.2017.12.021

From this research we know that
4.1
Gilbert's Syndrome may decrease BMI
1.2
Gilbert's Syndrome may inhibit Weight gain
(BioMindmap Proof Quality is Low.)
1.5
Gilbert's Syndrome may prevent CVD
(BioMindmap Proof Quality is Low.)
7.0
Gilbert's Syndrome decreases LDL
+1
0.3
Fat Mass may improve Gilbert's Syndrome
(BioMindmap Proof Quality is Very Light.)
0.4
Gilbert's Syndrome may decrease Waist-hip-ratio
(BioMindmap Proof Quality is Very Light.)
0.8
Gilbert's Syndrome may prevent Obesity
(BioMindmap Proof Quality is Very Light.)

2013

Cohort

Haem catabolism: a novel modulator of inflammation in Gilbert's syndrome.
Wallner M, et al.
«RESULTS: Gilbert's syndrome subjects had significantly greater levels of unconjugated bilirubin (P < 0.05), carboxy haemoglobin (P < 0.05), iron (P < 0.05), IL-1β (P < 0.05), a significantly lower body mass index (P < 0.05) and IL-6 concentration (P < 0.05) vs. controls. Regression analysis revealed that unconjugated bilirubin mainly explained IL-1β results (16%), and body mass index+IL-6 predicted 26% of the variance in C-reactive protein concentration.

CONCLUSIONS: A positive relationship between unconjugated bilirubin and free plasma haem, iron and carboxy haemoglobin indicated a positive feedback loop of haem oxygenase induction possibly mediated by unconjugated bilirubin. Furthermore, reduced body mass index in Gilbert's syndrome individuals was linked to reduced inflammation status, which could be influenced by circulating haem oxygenase catabolites and contribute to reduced risk of noncommunicable diseases in this population.»
Organism: Humans
#80 and over, Adult, Aged, Aged, Bilirubin, C-Reactive Protein, Carboxyhemoglobin, Case-Control Studies, Enzyme-Linked Immunosorbent Assay, Female, Gilbert Disease, Heme, Heme Oxygenase (Decyclizing), Humans, Interleukin-1beta, Interleukin-6, Male, Middle Aged, Tumor Necrosis Factor-alpha, Young Adult
ncbi.nlm.nih.gov/pubmed/23865893
Read 10.1111/eci.12120

From this research we know that
4.1
Gilbert's Syndrome may decrease BMI
5.1
Gilbert's Syndrome decreases IL-6
0.6
Gilbert's Syndrome may increase IL-1β
(BioMindmap Proof Quality is Very Light.)
0.6
Gilbert's Syndrome may increase Free plasma haem
(BioMindmap Proof Quality is Very Light.)
0.6
Gilbert's Syndrome may increase Carboxy haemoglobin
(BioMindmap Proof Quality is Very Light.)
0.8
Gilbert's Syndrome may increase Iron
(BioMindmap Proof Quality is Very Light.)

2013

Cohort

Protection from age-related increase in lipid biomarkers and inflammation contributes to cardiovascular protection in Gilbert's syndrome.
Wallner M, et al.
«Recent epidemiological and clinical data show protection from CVD (cardiovascular disease), all-cause mortality and cancer in subjects with GS (Gilbert's syndrome), which is characterized by a mildly elevated blood bilirubin concentration. The established antioxidant effect of bilirubin, however, contributes only in part to this protection. Therefore we investigated whether mildly elevated circulating UCB (unconjugated bilirubin) is associated with altered lipid metabolism. The study was performed on GS and age- and gender-matched healthy subjects (n=59 per group). Full lipoprotein profile, TAG (triacylglycerol), Apo (apolipoprotein)-A1, Apo-B, lipoprotein(a), the subfractions of LDL (low-density lipoprotein) and selected pro-inflammatory mediators were analysed. A hyperbilirubinaemic rodent model (Gunn rats, n=40) was investigated to further support the presented human data. GS subjects had significantly (P<0.05) improved lipid profile with reduced total cholesterol, LDL-C (LDL-cholesterol), TAG, low- and pro-atherogenic LDL subfractions (LDL-1+LDL-2), Apo-B, Apo-B/Apo-A1 ratio and lower IL-6 (interleukin 6) and SAA (serum amyloid A) concentration (P=0.094). When the control and GS groups were subdivided into younger and older cohorts, older GS subjects demonstrated reduced lipid variables (total cholesterol and LDL-C, TAG and LDL-C subfractions, Apo-B/Apo-A1 ratio; P<0.05; Apo-B: P<0.1) compared with controls. These data were supported by lipid analyses in the rodent model showing that Gunn rat serum had lower total cholesterol (2.29±0.38 compared with 1.27±0.72 mM; P<0.001) and TAG (1.66±0.67 compared with 0.99±0.52 mM; P<0.001) concentration compared with controls. These findings indicate that the altered lipid profile and the reduced pro-inflammatory status in hyperbilirubinaemic subjects, particularly in the older individuals, probably contribute additionally to the commonly accepted beneficial antioxidant effects of bilirubin in humans.»
Organism: Humans
Comments: After age and gender
matching, GS subjects showed a trend towards lower BMI than
the respective controls (P = 0.075).
#Adult, Aging, Animal, Animals, Bilirubin, Biomarkers, Cardiovascular Diseases, Case-Control Studies, Disease Models, Female, Gilbert Disease, Gunn, Humans, Inflammation, Lipoproteins, Male, Middle Aged, Rats, Rats, Young Adult
ncbi.nlm.nih.gov/pubmed/23566065
Read 10.1042/CS20120661

From this research we know that
2.5
Gilbert's Syndrome decreases Triglycerides
(BioMindmap Proof Quality is Acceptable.)
4.1
Gilbert's Syndrome may decrease BMI
1.5
Gilbert's Syndrome may prevent CVD
(BioMindmap Proof Quality is Low.)
1.5
Gilbert's Syndrome may lower Serum Amyloid A
(BioMindmap Proof Quality is Low.)
1.8
Gilbert's Syndrome reduces Apolipoprotein B
(BioMindmap Proof Quality is Low.)
2.5
Gilbert's Syndrome decreases Cholesterol
(BioMindmap Proof Quality is Acceptable.)
5.1
Gilbert's Syndrome decreases IL-6
7.0
Gilbert's Syndrome decreases LDL
+1
1.5
Gilbert's Syndrome may increase Bilirubin
(BioMindmap Proof Quality is Low.)
1.4
Gilbert's Syndrome reduces Apo-A1
(BioMindmap Proof Quality is Low.)
1.8
Gilbert's Syndrome reduces SAA
(BioMindmap Proof Quality is Low.)
1.5
Serum Amyloid A is marker of CVD
(BioMindmap Proof Quality is Low.)
1.5
Apo-B/Apo-A1 ratio is marker of CVD
(BioMindmap Proof Quality is Low.)
0.6
Gilbert's Syndrome may reduce IDL-3
(BioMindmap Proof Quality is Very Light.)
-2.4
Perhaps, Gilbert's Syndrome may reduce LDL-1
(BioMindmap Proof Quality is Negative.) (BioMindmap had flagged this statement.)
1.8
IL-6 induces CRP
(BioMindmap Proof Quality is Low.)
0.8
CRP may increase CVD
(BioMindmap Proof Quality is Very Light.)
0.6
CRP may increase Diabetes Type 2
(BioMindmap Proof Quality is Very Light.)
0.6
Gilbert's Syndrome may decrease IDL
(BioMindmap Proof Quality is Very Light.)
0.8
Gilbert's Syndrome may decrease VLDL
(BioMindmap Proof Quality is Very Light.)
0.6
Gilbert's Syndrome may decrease Apo-B/Apo-A1 ratio
(BioMindmap Proof Quality is Very Light.)

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