Gilbert's Syndrome
may decrease
BMI
Gilbert's Syndrome
may decrease
BMI
4.1
ValidityScore
Valid or Invalid?
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2017Cohort
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Seyed Khoei N, et al. -
The results presented highlight the potential of bilirubin
metabolism in contributing to the prevention of overweight/
obesity, particularly during aging. In our study, 25% of GS subjects,
compared to 46% in the HCG were overweight/obese. In the older
subgroup (mean age: 52 yrs), these figures increased to 35% and
69%, respectively. Data analysis revealed significantly lower
abdominal obesity in GS compared to the HCG, indicated by a
smaller HC and WC, remarkably in the older group. - Organism: Humans
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2013Cohort
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Wallner M, et al. -
«RESULTS: Gilbert's syndrome subjects had significantly greater levels of unconjugated bilirubin (P < 0.05), carboxy haemoglobin (P < 0.05), iron (P < 0.05), IL-1β (P < 0.05), a significantly lower body mass index (P < 0.05) and IL-6 concentration (P < 0.05) vs. controls. Regression analysis revealed that unconjugated bilirubin mainly explained IL-1β results (16%), and body mass index+IL-6 predicted 26% of the variance in C-reactive protein concentration.
- Organism: Humans
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#80 and over, Adult, Aged, Aged, Bilirubin, C-Reactive Protein, Carboxyhemoglobin, Case-Control Studies, Enzyme-Linked Immunosorbent Assay, Female, Gilbert Disease, Heme, Heme Oxygenase (Decyclizing), Humans, Interleukin-1beta, Interleukin-6, Male, Middle Aged, Tumor Necrosis Factor-alpha, Young Adult -
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2013Cohort
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Wallner M, et al. -
«Recent epidemiological and clinical data show protection from CVD (cardiovascular disease), all-cause mortality and cancer in subjects with GS (Gilbert's syndrome), which is characterized by a mildly elevated blood bilirubin concentration. The established antioxidant effect of bilirubin, however, contributes only in part to this protection. Therefore we investigated whether mildly elevated circulating UCB (unconjugated bilirubin) is associated with altered lipid metabolism. The study was performed on GS and age- and gender-matched healthy subjects (n=59 per group). Full lipoprotein profile, TAG (triacylglycerol), Apo (apolipoprotein)-A1, Apo-B, lipoprotein(a), the subfractions of LDL (low-density lipoprotein) and selected pro-inflammatory mediators were analysed. A hyperbilirubinaemic rodent model (Gunn rats, n=40) was investigated to further support the presented human data. GS subjects had significantly (P<0.05) improved lipid profile with reduced total cholesterol, LDL-C (LDL-cholesterol), TAG, low- and pro-atherogenic LDL subfractions (LDL-1+LDL-2), Apo-B, Apo-B/Apo-A1 ratio and lower IL-6 (interleukin 6) and SAA (serum amyloid A) concentration (P=0.094). When the control and GS groups were subdivided into younger and older cohorts, older GS subjects demonstrated reduced lipid variables (total cholesterol and LDL-C, TAG and LDL-C subfractions, Apo-B/Apo-A1 ratio; P<0.05; Apo-B: P<0.1) compared with controls. These data were supported by lipid analyses in the rodent model showing that Gunn rat serum had lower total cholesterol (2.29±0.38 compared with 1.27±0.72 mM; P<0.001) and TAG (1.66±0.67 compared with 0.99±0.52 mM; P<0.001) concentration compared with controls. These findings indicate that the altered lipid profile and the reduced pro-inflammatory status in hyperbilirubinaemic subjects, particularly in the older individuals, probably contribute additionally to the commonly accepted beneficial antioxidant effects of bilirubin in humans.»
- Organism: Humans
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Comments:
After age and gender
matching, GS subjects showed a trend towards lower BMI than
the respective controls (P = 0.075). -
- From this research we know that
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-2.4Perhaps, Gilbert's Syndrome may reduce LDL-1(BioMindmap Proof Quality is Negative.) (BioMindmap had flagged this statement.)
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on Apr 12, 2019