Gilbert syndrome and ischemic heart disease: a protective effect of elevated bilirubin levels.
Vítek L , et al.
«RESULTS: The prevalence of IHD in GS subjects (aged 49.7+/-9.0 years) was 2% (0.05-10.7%, 95% confidence interval), compared to 12.1% in a general population (P<0.05). Bilirubin, total antioxidant capacity and high density lipoprotein (HDL) cholesterol were found to be significantly higher in GS subjects compared to control groups (P<0.05). According to linear discriminant analysis, hyperbilirubinemia rather than elevation of HDLcholesterol levels seemed to be more important in protection from IHD.
CONCLUSIONS: In the present study, low prevalence of IHD in GS subjects was detected. It may be presumed that chronic hyperbilirubinemiaprevent the development of IHD by increasing the serum antioxidant capacity.»