Edit Gilbert's Syndrome decreases TAG
2.2
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2018
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Bulmer AC, et al. -
«Bilirubin, a potentially toxic catabolite of heme and indicator of hepatobiliary insufficiency, exhibits potent cardiac and vascular protective properties. Individuals with Gilbert's syndrome (GS) may experience hyperbilirubinemia in response to stressors including reduced hepatic bilirubin excretion/increased red blood cell breakdown, with individuals usually informed by their clinician that their condition is of little consequence. However, GS appears to protect from all-cause mortality, with progressively elevated total bilirubin associated with protection from ischemic heart and chronic obstructive pulmonary disease. Bilirubin may protect against these diseases and associated mortality by reducing circulating cholesterol, oxidative lipid/protein modifications, and blood pressure. In addition, bilirubin inhibits platelet activation and protects the heart from ischemia-reperfusion injury. These effects attenuate multiple stages of the atherosclerotic process in addition to protecting the heart during resultant ischemic stress, likely underpinning the profound reduction in cardiovascular mortality in hyperbilirubinemic GS. This review outlines our current knowledge of and uses for bilirubin in clinical medicine and summarizes recent progress in revealing the physiological importance of this poorly understood molecule. We believe that this review will be of significant interest to clinicians, medical researchers, and individuals who have GS.»
- Comments: Endothelial dysfunction contributes to the early stages of atherosclerosis, whereby 97 expression of adhesion molecules and oxidant generating NADPH oxidase (NOX) draws 98 leukocytes to sites of injury/lipid accumulation, propagating vascular injury and encouraging 99 vascular smooth muscle proliferation and neointima formation. Increased NOX driven 100 reactive oxygen species (ROS) production and intimal thickening contribute to hypertension 101 and impaired vasodilatation, involving sequestration of released nitric oxide. Based upon its 102 ROS neutralizing antioxidant properties, it is hypothesized that bilirubin has the potential to 103 reduce or prevent endothelial dysfunction.
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- From this research we know that
- Gilbert's Syndrome may decrease Thrombosis
- Gilbert's Syndrome decreases TAG
- Gilbert's Syndrome may prevent Atherosclerosis
- Gilbert's Syndrome inhibits Collagen
- Gilbert's Syndrome decreases Cholesterol
- Gilbert's Syndrome decreases LDL
- Atazanavir may worsen Gilbert's Syndrome
- Gilbert's Syndrome may inhibit Atherosclerosis
- Gilbert's Syndrome may decrease Intima-media thickness
- Gilbert's Syndrome may cause Thrombocytopenia
- Bilirubin may cause Thrombocytopenia
- Bilirubin may cause Platelet apoptosis
- Gilbert's Syndrome may cause Platelet apoptosis
- Bilirubin may inhibit Thrombosis
- Bilirubin inhibits Collagen
- Bilirubin improves Atherosclerotic plaques
- Gilbert's Syndrome improves Atherosclerotic plaques
- Atazanavir increases Antioxidant capacity
- Atazanavir may decrease Blood pressure
- Atazanavir increases Bilirubin
- Exercise may worsen Gilbert's Syndrome
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2013
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Wallner M, et al. -
Comments:
Pro-inflammatory markers
SAA is a pro-inflammatory adipokine in humans linked to
obesity and is a predictor of CVD [24,41] -
- From this research we know that
- Gilbert's Syndrome may decrease BMI
- Gilbert's Syndrome may prevent CVD
- Gilbert's Syndrome may lower Serum Amyloid A
- Gilbert's Syndrome decreases TAG
- Gilbert's Syndrome reduces Apolipoprotein B
- Gilbert's Syndrome decreases Cholesterol
- Gilbert's Syndrome decreases IL-6
- Gilbert's Syndrome decreases LDL
- Gilbert's Syndrome may increase Bilirubin
- Gilbert's Syndrome reduces Apo-A1
- Gilbert's Syndrome reduces SAA
- Gilbert's Syndrome may reduce IDL-3
- Gilbert's Syndrome may reduce LDL-1
- IL-6 induces CRP
- CRP may increase CVD
- CRP may increase Diabetes Type 2
- Gilbert's Syndrome may decrease IDL
- Gilbert's Syndrome may decrease VLDL
- Gilbert's Syndrome may decrease Apo-B/Apo-A1 ratio
Modified 3 months ago
on Oct 24, 2019
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added it
10 months ago
on Apr 10, 2019