Paracetamol, with its well-known hepatotoxicity in overdose, has been studied in this area. A subgroup of those with GS have been found to shift metabolism to an oxidative pathway over a glucuronidation pathway, thereby increasing the toxic metabolites of paracetamol, namely cysteine and mercapturic acid conjugates. There have, however, been no reported cases of liver injury in this setting in the literature. Therefore, there is no good quality evidence that those with GS should avoid paracetamol use or alter the recommended dosage.


MoreVitaminovPRO ranked added it 1 year ago on Apr 8, 2019