«Gilbert's syndrome is a hereditary and benign disorder characterized by intermittent nonconjugated hyperbilirubinemia. A twenty-three- year-old patient with Gilbert syndrome and moderate acne vulgaris was started on isotretinoin at a dose of 20 mg/day. One month later, serum bilirubin levels were found to be significantly lower than that of the baseline levels. Recent studies in the literature also support that bilirubin levels tend to decrease in patients with Gilbert syndrome under oral isotretinoin therapy. This article is protected by copyright. All rights reserved.»
«RESULTS: In patients with Gilbert's syndrome, bilirubin levels showed substantial decrease over the 20-week follow-up, with more decrease after 10 weeks. None of the control group patients had significant increase in total bilirubin levels after 10 and 20 weeks of follow-up. Liver enzymes were maintained within normal levels in both groups. Both study groups did not show significant pathological increase in lipid profile levels. LDL levels were increased in the two study groups, but this increase was less substantial in patients with Gilbert's syndrome.
CONCLUSIONS: Our preliminary results suggest that oral isotretinoin could be an effective, safe treatment for patients with Gilbert's syndrome, and may lowerbilirubin levels in the first 10 weeks of treatment. Limitations of the study include the small numbers of participants and the fact that it is restricted to one region of Spain.»
«Because of the potential hepatotoxicity of retinoids, prescription of isotretinoin is always very carefully made in healthy subjects, and prohibited in case of concomitant hepatopathy. Gilbert's syndrome consists of chronic, mild, unconjugated hyperbilirubinemia. In this syndrome, isotretinoin has been reported twice to be perfectly tolerated, and once even beneficial. We report here a new case of good tolerance and even improvement of a Gilbert's syndrome during isotretinoin therapy.»