Create BioLink with same Sources
Elevated Plasma Vitamin B12 Levels as a Marker for Cancer: A Population-Based Cohort Study
Johan Frederik Berg Arendt, Lars Pedersen, Ebba Nexo, Henrik Toft Sørensen
«High Cbl levels were associated with the risk of subsequently diagnosed cancer, mostly within the first year of follow-up.»
«RESULTS: We identified 333 667 persons without prevalent cancer and not receiving Cbl treatment. Six percent had Cbl levels greater than the upper reference limit (≥601 pmol/L). Cancer risk increased with higher Cbl levels and was highest during the first year of follow-up (Cbl 601–800 pmol/L: SIR = 3.44, 95% CI = 3.14 to 3.76; Cbl >800 pmol/L: SIR = 6.27, 95% CI = 5.70 to 6.88; both P < .001). The risks were particularly elevated for hematological and smoking- and alcohol-related cancers for persons with high Cbl levels.
CONCLUSIONS: High Cbl levels were associated with the risk of subsequently diagnosed cancer, mostly within the first year of follow-up. This may have clinical implications for the interpretation of high Cbl levels.»
Class D. Opinion of experts
Modified: 5 months ago
on Mar 28, 2019
5 months ago
on Mar 27, 2019.