Magnesium
lowers
Calcification
Magnesium
lowers
Calcification
9.3
ValidityScore
Valid or Invalid?
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2018
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Anique D. ter Braake, Catherine M. Shanahan, Jeroen H. F. de Baaij, Joost G. J. Hoenderop, Paul T. Tinnemans
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«RESULTS: BGP is a Pi-donor that requires enzymatic cleavage in order to release Pi. As Pi exposure is one of the decisive factors in the calcification process, the Pi concentration of the cell culture supernatant was assessed after 2, 8 and 14 days of treatment (Fig. 1). 10 mM BGP treatment resulted in gradual increase in Pi concentration over time, reaching 4.6 ± 0.3 mM after 14 days. 2 mM Mg2+ supplementation led to significantly higher Pi concentration of 7.6 ± 0.8 mM after 14 days. In contrast, BGP treatment in cell-free conditions did not lead to increased Pi concentration under the same conditions (data not shown).»
- Organism: In vitro
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2017RCT
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Bressendorff I, et al.
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Introduction: Chronic kidney disease (CKD) is associated with high cardiovascular morbidity and mortality. Recent evidence suggests that increases in both serum and intracellular magnesium (Mg) can slow or even prevent the development of vascular calcification seen in CKD. Serum calcification propensity (T50) is a novel functional test, which is associated with all-cause mortality in CKD and measures the ability of serum to delay the formation of crystalline nanoparticles. Theoretically, increasing serum Mg should improve T50 and thereby reduce the propensity towards ectopic calcification.
- Organism: Humans
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2017Publications Review
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Villa-Bellosta R
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«Conclusion: Data from observational clinical studies showing that the serum magnesium concentration is inversely correlated with vascular calcification could be reinterpreted as a compensatory regulatory mechanism that reduces both PPi hydrolysis and vascular calcification. The impact of magnesium in vascular calcification in humans could be studied in association with calcium levels, for example, as the magnesium:calcium ratio.»
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#Animals, Aorta / metabolism*, Aorta / pathology, Calcinosis*, Calcium / metabolism*, Kinetics, MEDLINE, Magnesium / metabolism*, NCBI, NIH, NLM, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, PMC5453594, PubMed Abstract, Rats, Ricardo Villa-Bellosta, Vascular Calcification*, doi:10.1371/journal.pone.0178872, pmid:28570619
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2014RCT
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Damianakis NE, Giannakis N, Oreopoulos DG, Papadaki AN, Stamataki EE, Tzanakis IP
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Background: The aim of the study was to evaluate the impact of magnesium (Mg) on the evolution of arterial calcifications in hemodialysis patients.
Patients and methods: Seventy-two stable hemodialysis patients were randomly allocated to two groups: 36 administered a regimen containing magnesium carbonate plus calcium acetate as a phosphate binder (Mg group), while the rest 36 received calcium acetate alone (Ca group). The presence and the progression of arterial calcifications were evaluated in plain X-rays using a simple vascular calcification score. The duration of the follow-up period was 12 months. - Organism: Humans
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added it
2 years ago
on Jan 9, 2019
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