Leaky gut in alcoholic cirrhosis: a possible mechanism for alcohol-induced liver damage.
Keshavarzian A , et al.
«Alcoholics with noliverdisease showed a small but significantincrease in sucrose excretion. Alcoholics with chronic liver disease demonstrated a marked and highly significantincrease in urinary sucrose excretion relative to the controls, to the alcoholics with noliverdisease, and to the nonalcoholics with liverdisease. Alcoholics with chronic liver disease demonstrated a marked and highly significantincrease in both lactulose absorption and in the urinary lactulose/mannitol ratio (alcoholics 0.703 vs controls 0.019, p = 0.01). In contrast, alcoholics with noliverdisease and nonalcoholics with liverdisease showed normal lactulose absorption and normal lactulose/mannitol ratio.»