Cat's claw inhibits TNF-α

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2001

Efficacy and safety of freeze-dried cat's claw in osteoarthritis of the knee: mechanisms of action of the species Uncaria guianensis.
Piscoya J, et al.
«Cat's claw had no deleterious effects on blood or liver function or other significant side-effects compared to placebo. Pain associated with activity, medical and patient assessment scores were all significantly reduced, with benefits occurring within the first week of therapy. Knee pain at rest or at night, and knee circumference were not significantly reduced by cat's claw during this brief trial. In vitro tests indicated that U guianensis and U. tomentosa were equivalent at quenching DPPH radicals (EC50, 13.6-21.7 microg/ml) as well as inhibiting TNFalpha production. However, the latter action was registered at much lower concentration (EC50, 10.2-10.9 ng/ml). Cat's claw (10 microg/ml) had no effect on basal PGE2 production, but reduced LPS-induced PGE2 release (P < 0.05), but at higher concentration than that required for TNFalpha inhibition.»
#Adult, Aged, Cat's Claw, Dinoprostone, Double-Blind Method, Free Radical Scavengers, Freeze Drying, Humans, Male, Medicinal, Middle Aged, Osteoarthritis, Pain Measurement, Plant Extracts, Plants, Prospective Studies, Prostaglandin Antagonists, Tumor Necrosis Factor-alphamore...
ncbi.nlm.nih.gov/pubmed/11603848
10.1007/PL00000268

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