QUIN induces Oxidative stress

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2017

Publications Review

Anti-inflammatory treatment for major depressive disorder: implications for patients with an elevated immune profile and non-responders to standard antidepressant therapy
Cristina M Moriguchi-Jeckel, Erik FJ de Vries, Hans C Klein, Janine Doorduin, Luis Eduardo Juárez-Orozco, Paula Kopschina Feltes, Rudi AJO Dierckx
« QUIN [Quinolinic acid] also increases glutamate release to neurotoxic levels, inducing oxidative and nitrosative stress (O&NS) in MDD.»
Strong Magnitude of Effect.
#Major depressive disorder, antidepressants, microglia, neuroinflammation, pro-inflammatory cytokines
ncbi.nlm.nih.gov/pmc/articles/PMC5606303
10.1177/0269881117711708

From this research we know that
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TNF-α increases ACTH
4.5
COX-1 may increase Neuron degeneration
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Arginine converts to Nitric Oxide
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Sirtuin regulates Mitochondrial function
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QUIN induces Oxidative stress
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Tryptophan Hydroxylase-2 decreases Noradrenaline
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IL-6 increases Indoleamine 2,3-Dioxygenase
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PGG2 converts to PGH2
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Nitrosative stress increases Lipid peroxidation
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Nitrosative stress increases Protein oxidation
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IL-2 increases Indoleamine 2,3-Dioxygenase
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Depression decreases Coenzyme Q10
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IL-1β increases Indoleamine 2,3-Dioxygenase
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Tryptophan Hydroxylase-2 decreases Dopamine
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Oxidative stress causes DNA damage
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Major depressive disorder increases Proinflammatory cytokines
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Indoleamine 2,3-Dioxygenase produces QUIN
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Phenylalanine hydroxylase decreases Noradrenaline
4.8
Major depressive disorder increases IL-1β
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TNF-α increases CRH
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Major depressive disorder increases TNF-α
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Tyrosine Hydroxylase decreases Dopamine
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COX-2 may increase Major depressive disorder
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Proinflammatory cytokines decrease BH4
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IL-6 increases Cortisol
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Phenylalanine hydroxylase decreases Serotonin
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Oxidative stress decreases Lipids
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QUIN increases RNS
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QUIN increases ROS
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Sirtuin regulates Circadian rhythm
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COX-1 may increase Major depressive disorder
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Major depressive disorder increases IFN-γ
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Indoleamine 2,3-Dioxygenase produces Kynurenic acid
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Sirtuin regulates Neurogenesis
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Nitrosative stress increases Inflammation
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Nitrosative stress causes DNA damage
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QUIN induces Nitrosative stress
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QUIN increases Glutamate
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Proinflammatory cytokines decrease Neurotransmitters
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Proinflammatory cytokines stimulate Nitric Oxide
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Tryptophan Hydroxylase-2 decreases Serotonin
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Tyrosine Hydroxylase decreases Serotonin
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Tyrosine Hydroxylase decreases Noradrenaline
4.7
Phenylalanine hydroxylase decreases Dopamine
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Depression decreases PUFA
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Depression decreases Zinc
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Depression decreases Vitamin C
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Depression decreases Vitamin E
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Depression decreases Glutathione
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Oxidative stress increases Inflammation
4.8
Oxidative stress decreases Proteins
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TNF-α increases Indoleamine 2,3-Dioxygenase
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NAD+ induces Sirtuin
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Major depressive disorder decreases Tryptophan
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Indoleamine 2,3-Dioxygenase produces NAD+
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IL-1β reduces Serotonin
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IFN-γ increases Indoleamine 2,3-Dioxygenase
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TNF-α reduces Serotonin
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IFN-γ reduces Serotonin
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IL-6 reduces Serotonin
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IL-2 reduces Serotonin
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TNF-α increases Cortisol
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IL-6 increases ACTH
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IL-6 increases CRH
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LPS increases Inflammation
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Major depressive disorder increases IL-6
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Major depressive disorder increases IL-18
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Major depressive disorder increases CRP

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